Simsek, SerefYuksel, TugbaKaplan, IbrahimUysal, CemAktas, Huseyin2024-04-242024-04-2420161738-36841976-3026https://doi.org/10.4306/pi.2016.13.6.616https://hdl.handle.net/11468/19737Objective The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. Methods The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method. Results Our evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD. Conclusion Although the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage.eninfo:eu-repo/semantics/openAccessCortisolDna DamageOxidative StressPtsdSexual AbuseTraumaArticle136616621WOS:0003887826000062-s2.0-850062777432790945210.4306/pi.2016.13.6.616Q2Q3