Alyan, OmerKacmaz, FehmiOzdemir, OzcanMaden, OrhanTopaloglu, SerkanOzbakir, CemalMetin, Fatma2024-04-242024-04-2420081082-720X1542-474Xhttps://doi.org/10.1111/j.1542-474X.2008.00213.xhttps://hdl.handle.net/11468/17634Background: Cigarette smoking increased the risk of acute cardiac events related with endothelial dysfunction and increased sympathetic activity. Impaired autonomic nervous activity is recognized as a considerable symptom of cardiac dysfunction and is strongly associated with increased risk overall mortality. Methods: A total of 75 healthy habitual smokers (40 female, 35 male, mean age 36.5 +/- 8.5 years), and 73 non-smokers subjects (45 female, 28 male, mean age 34.6 +/- 7.2 years) were studied. LF and LF/HF ratio were significantly higher in smokers than in non-smokers. On the contrary, SDNN, SDANN, RMSSD, and HF values were lower in smokers compared to those in non-smokers. Not the duration of smoking but the number of cigarettes smoked per day was correlated with the HRV parameters and NT-pro BNP. Furthermore, the average levels of NT-pro BNP were found to be positively correlated with LF, LF/HF and inversely correlated with SDNN, SDANN, RMSSD and HF. Results: As a result, smoking impaires sympathovagal balance and decreases the heart rate variability in healthy subjects. And even a one cigarette smoking leads to overt sympathetic excitation. Furthermore, smoking results in an increase in NT-proBNP levels and the changes in adrenergic nervous system and NT-proBNP levels are well correlated. Conclusion: These findings could contribute to the higher rate of cardiovascular events in smokers.eninfo:eu-repo/semantics/openAccessElectrophysiologyAutonomic Nervous System And ClinicalNoninvasive TechniquesHeart Rate Variability And ClinicalArticle132137144WOS:0002551355000062-s2.0-424491248001842643910.1111/j.1542-474X.2008.00213.xQ2Q3