Bingül, MuratŞahin, Hasan2024-02-272024-02-272023Bingül, M. ve Şahin, H. (2023). Hypoglycemic potential of 4,6-dimethoxyindole-7- and -2-thiosemicarbazone derivatives. Socrates 8th International Health, Engineering And Applied Sciences Congress, 28-30 September 2023. (pp. 69-73). Diyarbakır: Dicle University.https://hdl.handle.net/11468/13400The hybrid molecules, derived from biologically active compounds, have been an open target for the medical researchers due to the possible enhanced biological properties. Hybridization of biologically active compounds for the determination of new possible candidates for drug development has been an attractive idea and allow to detect new successful compounds for drug discovery. With respect to this idea, previously synthesized dimethoxyindole based thiosemicarbazones have been chosen as hybrid molecules derived from indole backbone and thiosemicarbazides which have heavily been used for biological studies and evaluated for inhibition of α-amylase and α-glucosidase to exhibit the hypoglycemic potential. The targeted molecules were found to be potent candidates for α-glucosidase enzyme inhibition compared to the standard. The inhibition potential for α-amylase was not comparable with the acarbose with the studied concentration, however, it was determined that the targeted compounds could be selective candidates for glucosidase enzyme inhibition and the future studies were directed for the identification new compounds for this purpose.eninfo:eu-repo/semantics/openAccessDimethoxyindoleThiosemicarbazoneα-amylaseα-glucosidaseConference Object6973