Pirinccioglu, Ayfer GozuAlyan, OmerAkin, AlperKizil, GokselIsik, Fatma Birgul2024-04-242024-04-2420191328-80671442-200Xhttps://doi.org/10.1111/ped.13983https://hdl.handle.net/11468/17735Background The aim of this study was to investigate of the role of oxidative stress (OS) in acute rheumatic fever (ARF) and its relationship with the progress of the disease. Methods Thirty patients with ARF and 31 age-sex-matched healthy children were enrolled in this study. Serum malondialdehyde (MDA), protein carbonyl (PCO), high-sensitivity C-reactive protein (hs-CRP), cytokines (tumor necrosis factor-alpha and interleukin-6) and total antioxidant capacity (TAC) were measured. The diagnosis of ARF was based on the Jones criteria. Results Patients with ARF had significantly higher serum MDA, PCO, hs-CRP and cytokine levels and lower TAC than healthy controls. On Pearson's correlation analysis we found that oxidative stress markers were positively correlated with hs-CRP and cytokines, while TAC was negatively correlated with MDA, PCO, hs-CRP and cytokines. The number of valves involved as well as the level of mitral valve involvement was also significantly related to the oxidative stress parameters and TAC. All oxidative stress parameters decreased significantly with anti-inflammatory therapy while TAC increased. Conclusion Malondialdehyde and PCO, as biomarkers, as well as hs-CRP together with the other available diagnostic tools, can be used in the evaluation of patients with ARF.eninfo:eu-repo/semantics/closedAccessAcute Rheumatic FeverLipid PeroxidationOxidative StressProtein OxidationTotal Antioxidant CapacityArticle6110962966WOS:0004931170000042-s2.0-850742028323133288510.1111/ped.13983Q3Q4