Uluca, ÜnalŞen, VelatEce, AydınTan, İlhanKarabel, DuranAktar, FesihKarabel, MüsemmaBalık, HasanGüneş, Ali2024-04-242024-04-242015Uluca, Ü., Şen, V., Ece, A., Tan, İ., Karabel, D., Aktar, F. ve diğerleri. (2015). Serum galectin-3 levels in children with chronic hepatitis B infection and inactive hepatitis B carriers. Medical Science Monitor, 21, 1376-1380.1234-1010https://doi.org/10.12659/MSM.894035https://hdl.handle.net/11468/23591Background: Chronic hepatitis B virus (HBV) infection is common worldwide. Follow-up of patients by the use of non-invasive techniques may be valuable in clinical practice. The aim of this study was to investigate serum galectin-3 (GAL-3) levels for monitoring disease status in children with chronic HBV infection. Material/Methods: Thirty-two patients with chronic hepatitis B (CHB), 30 inactive HBV carrier patients, and 30 matched healthy controls were enrolled in the study. We performed basic laboratory tests: serum glucose, albumin, alanine aminotransferase (ALT), aspartate aminotransferase, gamma-glutamyl transferase (GGT), total bilirubin, prothrombin time, and activated partial thromboplastin time. In addition, serum GAL-3 levels were measured by ELISA technique. Results: Significantly higher serum GAL-3 levels (16.5±3.6, 1.1±0.3, 0.7±0.5 ng/ml, respectively, p<0.001) and ALT levels (80.2±30.6, 26.8±12.6, 28.1±4.4 IU/L, respectively, p<0.001) were found in the CHB group compared with the inactive carriers and the control groups. There were no significant differences in ALT levels and GAL-3 levels or between inactive HBV carriers and the control groups (p>0.05, for each). Significantly higher GGT levels were found in the CHB group (51.3±27.5 IU/L) compared with the inactive HBV carriers (35.7±10.1 IU/L) and the control group (31.3±9.5 IU/L) (p<0.001, and p=0.004, respectively). A significant correlation was found between GAL-3 and ALT levels in the CHB group (r=0.82, p<0.001). Conclusions: Our results suggest that serum GAL-3 level may be a beneficial indicator of chronicity in hepatitis B infection in children.eninfo:eu-repo/semantics/openAccessChildChronicGalectin 3Hepatitis BArticle2113761380WoSIDEksik2-s2.0-849293924672596824910.12659/MSM.894035Q1N/A