Ece, ATekes, SGürkan, FBilici, MBudak, T2024-04-242024-04-2420051320-5358https://doi.org/10.1111/j.1440-1797.2005.00430.xhttps://hdl.handle.net/11468/17590Aim: The aim of this study was to investigate whether the angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor (A1166C) gene polymorphisms were associated with the renal scar formation secondary to recurrent urinary tract infection in children without uropathy. Methods: The polymorphisms were investigated by polymerase chain reaction in 97 children (81 females, 16 males; age, 2.5-13 years) with recurrent urinary tract infection and 100 healthy controls as a single centre study. Children with vesicoureteral reflux, bladder dysfunction and other uropathies were excluded. The dimercaptosuccinic acid (DMSA) scan performed at least 3 months after a proven urinary tract infection and the result of the last DMSA was taken into consideration. Results: Renal scarring was found in 30 patients (30.9%) using DMSA scan. The number of urinary tract infection attacks was significantly higher in patients with renal scarring compared with children without scarring (P < 0.05). The follow-up period and male/female ratio of patients with or without renal scarring was similar (P > 0.05). Age at the first urinary tract infection was lower in the group with scarring. The ACE insertion/deletion genotype distribution and D allele frequency were similar between patients and controls (P > 0.05), and in patients with renal scarring and those without renal scarring. Also, the angiotensin II type 1 receptor gene polymorphism was not associated with renal parenchymal damage (P > 0.05). Conclusion: The results indicated that the ACE insertion/deletion and angiotensin II type 1 receptor gene polymorphisms were not independent risk factors for renal scar formation in recurrent urinary tract infection of paediatric patients without uropathy.eninfo:eu-repo/semantics/closedAccessAngiotensin Converting Enzyme GeneAngiotensin Ii Type 1 Receptor GenePolymorphismRenal ScarringUrinary Tract InfectionArticle104377381WOS:0002311521000112-s2.0-284444521731610908510.1111/j.1440-1797.2005.00430.xQ2Q3