Dal, M. S.Karakus, A.Aydin, B. B.Ekmen, M. O.Ulas, T.Ayyildiz, O.2024-04-242024-04-2420151128-3602https://hdl.handle.net/11468/21307OBJECTIVE: The purpose of this study was to evaluate the uric acid (UA) and Creactive protein (CRP) levels in patients with immune thrombocytopenic purpura (ITP). PATIENTS AND METHODS: Forty patients with newly diagnosed ITP and 40 healthy individuals were enrolled in the study. The patients were divided into two groups; group 1 (n = 40) consisted of patients with ITP, and group 2 (n = 40) consisted of healthy subjects. UA and CRP levels were measured in the blood samples from them. RESULTS: There were no statistical differences in gender, age and body mass index between two groups (p > 0.05 for all). Compared to group 2, group 1 had significantly higher UA levels (p = 0.002), whereas CRP levels were not significantly different (p > 0.05). In ITP patients, serum UA and CRP levels significantly correlated with low platelet count (r = -0.362, p = 0.022; r = -0.383, p = 0.015, respectively); and UA levels significantly correlated with CRP levels (r = 0.436, p = 0.005). CONCLUSIONS: The present study showed that UA levels increased in patients with ITP and negatively correlated with platelet counts. UA levels might be a mediator of inflammation via enhanced production of inflammatory cytokines; they might also be a potential mediator of low platelet count, and could play a pathophysiological role in the development of ITP.eninfo:eu-repo/semantics/closedAccessC-Reactive ProteinImmune Thrombocytopenic PurpuraUric AcidArticle192243854389WOS:0003667574000262-s2.0-8495795870126636527Q2Q3