Ülger, Burak VeliDurgun, Hasan MansurAşır, FıratVarlı, MetinGündüz, Ercan2024-04-242024-04-242023Ülger, B.V., Aşır, F., Varlı, M., Gündüz, E. ve Durgun, H.M. (2023). Efficacy of taxifolin in the prevention of renal injury due to liver ischemia and reperfusion. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, 6(3), 503-507.2667-498Xhttps://doi.org/10.36516/jocass.1371823https://search.trdizin.gov.tr/yayin/detay/1222213https://hdl.handle.net/11468/28622Aim: During surgical procedures such as liver resection and transplantation, ischemia/reperfusion (I/R) injury and related complications may occur at a rate of approximately 10%. Our study, we planned to investigate histologically and biochemically the efficacy of Taxifolin in the prevention of renal tissue damage in liver ischemia reperfusion. Methods: A total of 28 Wistar Albino rats with an average age of 8-10 weeks and weights of 250-300 grams were used in our study. Group 1 (n=7): control group, Group 2 (n=7): Taxifolin group; Taxifolin was administered orally at a dose of 50 mg/kg for 3 weeks, Group 3 (n=7): Liver I/R group, 30 minutes ischemia and 120 minutes reperfusion was performed. Group 4 (n=7): Taxifolin+Liver I/R group. Results: Kidney tissues of the liver I/R group showed atrophy, degeneration of tubule epithelium and increased TNF-? expression. In addition, deterioration in renal function tests was also monitored in this group. In the Taxifolin+Liver I/R group, a significant difference was observed on both histologic and biochemical basis compared to the Liver I/R group and a positive effect was observed (p<0.05). Outcome: As a consequence of hepatic ischemia and reperfusion, impairment in the function and histological appearance of renal tissues was observed and Taxifolin was monitored to be effective in eliminating these adverse effects.eninfo:eu-repo/semantics/openAccessLiver ischemiaReperfusionTaxifolinHistopathologyImmunohistochemistryOxidative stressArticle63503507122221310.36516/jocass.1371823