Akocak, SüleymanLolak, NabihTuneğ, MuhammedBoǧa, Mehmet2021-10-012021-10-012019Akocak, S., Lolak, N., Tuneğ, M. ve Boǧa, M. (2019). Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff bases. Journal of the Turkish Chemical Society, Section A: Chemistry, 6(2), 157-164.2149-0120https://dergipark.org.tr/en/pub/jotcsa/issue/43285/521291https://hdl.handle.net/11468/7857https://search.trdizin.gov.tr/yayin/detay/396154In this work, a series of histamine Schiff bases H(1-20) were assayed for antioxidant properties by using different bioanalytical methods such as DPPH-free radical scavenging assay, ABTS cation radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. In general, the synthesized compounds showed weak antioxidant activity against all tested methods, but some of them showed great inhibition potency against AChE and BChE enzymes. Specifically, compound H9 showed effective inhibition potency against both enzymes with percent inhibition of 97.03 and 93.64, respectively.eninfo:eu-repo/semantics/openAccessAlzheimer’s diseaseAnticholinesteraseAntioxidantHistamineSchiff baseArticle621571642-s2.0-8507050953939615410.18596/jotcsa.521291Q3