Anilir, EnderOzen, FilizOzemir, Ibrahim AliYildirim, Ibrahim HalilBilgic, CagriAlimoglu, Orhan2024-04-242024-04-2420182564-68502564-7032https://doi.org/10.5152/turkjsurg.2017.3828https://search.trdizin.gov.tr/yayin/detay/305737https://hdl.handle.net/11468/20031Objectives: There has been coverage of Toll-like receptor 4 and Toll-like receptor 2 gene polymorphisms in inflammatory episodes in a number of studies. In view of the inflammatory nature of acute pancreatitis, we aimed to determine the predictive value of mutations in Asp299Gly and Thr399Ile of the Toll-like receptor 4 gene, and the intron 2 microsatellite polymorphism of the Toll-like receptor 2 gene on the occurrence of acute biliary pancreatitis. Material and Methods: The study included 86 patients for the Toll-like receptor 4 Thr399Ile polymorphism, 100 patients for the Toll-like receptor 4 Asp299Gly polymorphism with acute biliary pancreatitis, and 101 healthy volunteers. At the same time, 93 patients and 92 healthy volunteers were included in the study to research the Toll-like receptor 2 intron 2 microsatellite polymorphism. Genotypes were determined using the restriction fragment length polymorphism analysis of PCR products and by an allele-specific PCR. Results: The Toll-like receptor 4 Thr399Ile homozygotes mutant variants (p=0.005) and Toll-like receptor 2 MM genotype (p<0.001) were detected with a significantly higher frequency in patients with acute biliary pancreatitis than in the healthy blood donors. Conclusion: The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and the Toll-like receptor 2 intron 2 microsatellite polymorphism are statistically associated with ABP.eninfo:eu-repo/semantics/openAccessAcute PancreatitisBiliaryGene PolymorphismToll-Like Receptor 2Toll-Like Receptor 4Article343191197WOS:0004462278000063057373021617910.5152/turkjsurg.2017.3828N/A