Boğa, MehmetÇınar, ErcanTopal, GirayÇakmak, Reşit2024-04-242024-04-2420222618-6136https://doi.org/10.51477/mejs.1204413https://search.trdizin.gov.tr/yayin/detay/1147727https://hdl.handle.net/11468/28503In this study, five novel Schiff base derivatives (6-10) except for 9 were synthesized for the first time, characterized, and tested for their inhibition activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Also, the Antioxidant activities of these molecules were examined by DPPH and ABTS assays. Their molecular structures were characterized by three spectroscopic techniques. In AChE assay, compound 6 (95.87±1.59 % inhibition) inhibited this enzyme better than galanthamine (76.98±0.42 % inhibition). In BChE assay, compound 10 with an 87.92±1.08% inhibition value in the series indicated the highest activity compared to galanthamine (76.30±0.28 % inhibition). In ABTS radical scavenging assay, compounds 7, 8, and 9 except for 6 and 10 indicated higher antioxidant activities compared to butylated hydroxytoluene (BHT). It is believed that these results may contribute to the design and synthesis of novel antioxidant agents, AChE, and BChE inhibitors.eninfo:eu-repo/semantics/openAccessArticle82138146114772710.51477/mejs.1204413