Ayaz, Simge GumusBakir, Elif PinarBakir, Seyhmus2025-02-222025-02-2220242146-2852https://doi.org/10.7126/cumudj.1448510https://search.trdizin.gov.tr/tr/yayin/detay/1268593https://hdl.handle.net/11468/29929Objectives: In this study, it was aimed to quantitatively evaluate the remineralization capacity of natural medicaments such as ginger, grape seed extract and rosemary, and materials containing casein and hydroxyapatite of initial caries lesions in vitro. Materials and Methods: 42 enamel samples obtained from human teeth; were divided into six group as; Group-I (10% Casein Phosphopeptide Amorphous Calcium Phosphate [CPP-ACP], GC Tooth Mousse, Group-II (Rosemary Oil), Group-III (ginger+honey), Group-IV (ginger+honey+cocoa), Group-V (grape seed extract) and Group-VI (control group; remineralization solution). After enamel samples were kept in demineralization solution for 72 hours to create initial caries lesion, grouped remineralization agents were applied to enamel samples with caries lesion during the six-day pH cycle. Measurements were made using surface microhardness and DIAGNOdent at three different stages. The data obtained in the research were analyzed using the SPSS 25.0 program. The results were evaluated at the p<0.05 significance level. Results: In surface microhardness measurements, all test materials showed significantly more remineralization than fluoride tooth cream, and grape seed extract was found to be the most successful group (p≤0.05). When all groups were compared with the positive control group, there were significant statistical differences between the groups (p≤0.05). The remineralization capacities of the groups whose activities were examined; grape seed extract> ginger+honey+cocoa>ginger+honey> rosemary oil > GC tooth mousse. Conclusions: It is thought that rosemary, ginger + honey + cocoa, grape seed extract materials can be used for remineralization in these working conditions where the initial caries lesions can be remineralized after six days. © (2024), (Cumhuriyet University Faculty of Dentistry). All rights reserved.eninfo:eu-repo/semantics/openAccessBiberiyeGingerGrape Seed ExtractMicrohardnessMikrosertlikRemineralizasyonRemineralizationRosemaryZencefilÜzüm Çekirdeği ÖzüArticle2741581652-s2.0-85206997743126859310.7126/cumudj.1448510Q4