Binbay, Nil E.Ziyadanogullari, Berrin2024-04-242024-04-2420180008-42041208-6045https://doi.org/10.1139/cjp-2017-0759https://hdl.handle.net/11468/1781033rd International Physics Conference of Turkish-Physical-Society (TPS) -- SEP 06-10, 2017 -- Konacik, TURKEYSaturation transfer difference nuclear magnetic resonance is a ligand-based screening technique that focuses directly on the physical interaction of a macromolecule (protein, enzyme, etc.) and a small ligand. It is a powerful tool in pharmaceutical research. Here, a comparison is reported of the binding characteristics of ibuprofen and a novel anti-inflammatory agent to cyclooxygenase-1 and cyclooxygenase-2 enzymes as an application of saturation transfer difference nuclear magnetic resonance. It has been shown that this novel agent is capable of binding to both isoforms of the cyclooxygenase enzymes. It has also been reported that novel agent binds better to cyclooxygenase-2.eninfo:eu-repo/semantics/openAccessNmrH-1Std-NmrCyclooxygenase-1Cyclooxygenase-2IbuprofenNsaidsComparison of binding properties of a novel non-steroidal anti-inflammatory agent and ibuprofen to cyclooxygenase-1 and cyclooxygenase-2 enzymes by saturation transfer difference nuclear magnetic resonanceComparison of binding properties of a novel non-steroidal anti-inflammatory agent and ibuprofen to cyclooxygenase-1 and cyclooxygenase-2 enzymes by saturation transfer difference nuclear magnetic resonanceConference Object967693699WOS:0004372935000072-s2.0-8504960115610.1139/cjp-2017-0759Q3Q3