Aybak, MSermet, AAyyildiz, MOKarakilcik, AZ2024-04-242024-04-2419950004-4172https://hdl.handle.net/11468/20762The purpose of this study was to test the effect of vitamin B-6 (pyridoxine-HCl, CAS 58-56-0) supplementation on arterial blood pressure in essential hypertension. The trial comprised 9 normotensive subjects (7 men and 2 women, aged between 32-58 years, mean +/- SD, 48 +/- 11) and 20 patients with essential hypertension (16 men and 4 women, aged between 32-69 years, mean +/- SD, 56 +/- 12). The patients were treated during 4 weeks with a single oral dose of pyridoxine (5 mg/kg body weight/day). After a 5-min rest, measurements were made in the supine position. When compared with the normotensive subjects, the hypertensive subject group had a significantly higher systolic and diastolic blood pressure (p < 0.001) and higher level of plasma norepinephrine (E) (p < 0.01) before pyridoxine treatment. On the other hand there, were no significant differences in plasma epinephrine (E) and heart rates. Treatment of hypertensive patients with pyridoxine significantly reduced systolic (p < 0.01) and diastolic blood pressure (p < 0.005), plasma NE (p < 0.005) and E (p < 0.05) within 4 weeks. However, there was no significant difference in heart rate at the end of pyridoxine treatment. These results indicate a relationship between pyridoxine status and arterial blood pressure in the essential hypertensive patients.eninfo:eu-repo/semantics/closedAccessCas 58-56-0Hypertension, EssentialPyridoxine, Clinical Studies, Effects On Blood PressureVitamin B-6Article45-21212711273WOS:A1995TN020000062-s2.0-00295690678595083N/AN/A