Tasdemir, NebahatTamam, YusufYalman, Mediha2024-04-242024-04-2420131300-06671309-4866https://doi.org/10.4274/npa.y6232https://search.trdizin.gov.tr/yayin/detay/156093https://hdl.handle.net/11468/19676Background: Although the etiology of multiple sclerosis (MS) has not yet been clearly elucidated, MS is a chronic inflammatory disease, in which genetic and environmental factors are involved. The association between apolipoprotein E (APOE) genetic polymorphisms and various neurodegenerative diseases, including MS, is controversial. In the current study, specific APOE genotypes were investigated in patients with MS. Methods: Fifty patients clinically diagnosed with MS and 30 healthy volunteers were included in the study. The APOE genotype was identified via the polymerase chain reaction (PCR) method. The patient and control groups were compared in terms of the frequency of APOE genotypes. Results: The APOE genotype distribution in the patient group was as follows: epsilon 3/epsilon 3, 82.0%; epsilon 3/epsilon 4, 12.0%; and epsilon 2/epsilon 3, 6.0%. There were no significant differences between the patient and control groups with respect to the frequency of APOE genotypes, and APOE epsilon 4 allele carriage (p=0.56). However, the frequency of APOE epsilon 4 allele carriers were significantly higher among male patients (p=0.007). Conclusion: These findings suggest that the APOE genotype has no effect on susceptibility to MS. Further studies with larger sample sizes to be able to include all APOE genotypes are warranted. Identification of genetic factors that may have a role in the etiology of MS will make a substantial contribution to the knowledge of the prevention and treatment of MS.eninfo:eu-repo/semantics/closedAccessMultiple SclerosisApolipoproteins EGenotypeNeurodegenerative DiseaseArticle502110115WOS:00032097270000315609310.4274/npa.y6232Q4