Arpağ, Osman FatihDamlar, İbrahimAltan, AhmetTatlı, UfukGünay, Ahmet2020-04-072020-04-072018Arpağ, O.F., Damlar, İ., Altan, A., Tatlı, U. ve Günay, A. (2018). To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model. Journal of Applied Oral Science, 26(18), 1-8.1678-77571678-7765https://hdl.handle.net/11468/5219http://www.scielo.br/pdf/jaos/v26/1678-7757-jaos-1678-7757-2017-0004.pdfJournal: Journal of Applied Oral Science (ISSN: 1678-7757, ESSN: 1678-7765) RoMEO: This is a RoMEO ungraded journal Listed in: DOAJ as an open access journal warning - This journal's policies have not been checked by RoMEO. - DOAJ says this is an open access journal, but this may only mean that it is freely available to read. - Most open access journals also permit self-archiving and re-use, but some do not. - Do not assume that self-archiving is allowed, unless it is published under a Creative Commons license. - Please contact the publisher for further information if necessary. - Please contact us if you wish to suggest adding this publisher properly to RoMEO Published by: University of São PauloAmong the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (p<0.05). The volume of residual graft was significantly decreased in HA group compared to xenograft group (p=0.035). Marrow space, trabecular thickness (TbTh), trabecular width (TbWi), trabecular separation (TbSp), and number of node: number of terminus (NNd:NTm) in the autograft group were significantly better than xenograft and HA groups (p<0.05). However, regarding marrow space, TbTh, TbWi, TbSp, and NNd:NTm values, xenograft and HA groups showed similar results and the difference were not significant (p>0.05). Conclusion: These results support that high molecular weight hyaluronic acid could contribute to the healing of xenograft by improving the percentage of new bone formation and reducing the percentage of residual graft. However, HA did not significantly affect the quality of newly formed bone assessed by microarchitectural parameters.eninfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 United Statesinfo:eu-repo/semantics/closedAccessHyaluronic acidXenograftHistological techniqueBone formationArticle261818WOS:0004232084000012-s2.0-850409879782936433710.1590/1678-7757-2017-0004Q1Q3