Guzel, RemziyeEksi, HasletDinc, ErdalSolak, Ali Osman2024-04-242024-04-2420191061-93481608-3199https://doi.org/10.1134/S1061934819030110https://hdl.handle.net/11468/17772A new voltammetric approach was developed for the determination of paracetamol in tablet and syrup samples using chemometric optimization. The method is based on the use of the gold nanoparticles-polyaniline (AuNPs-PA) modified pencil graphite electrode (PGE). Electrode system was fabricated by using the electrochemical reduction of gold on aniline modified pencil electrode to give gold nanoparticles. A 3(3) full factorial design was used to find optimal oxidation conditions of paracetamol on the AuNPs-PA-PGE. The optimal oxidation conditions of drug substance were found as -524 mV for the accumulation potential, 295 s for the accumulation time and pH 8.69 (for the phosphate buffer solution, 0.1 M). The determination of paracetamol was linear in the range of 2.0 x 10(-7)-6.0 x 10(-6) M with a detection limit of 5 x 10(-8) M. As a result, the proposed voltammetric approach gave satisfactory results for the determination of the related drug substance in tablets and syrup.eninfo:eu-repo/semantics/closedAccessExperimental Design And OptimizationGold NanoparticlesParacetamolPencil Graphite ElectrodeArticle743296305WOS:0004648756000112-s2.0-8506426500710.1134/S1061934819030110Q4Q4