Dede, OnurDagguli, MansurUtangac, MazharYuksel, HaticeBodakci, Mehmet NuriHatipoglu, Namik KemalSancaktutar, Ahmet Ali2024-04-242024-04-2420151940-5901https://hdl.handle.net/11468/21686Objective: To evaluated the damage effects of retrograde intra-renal surgery (RIRS) on kidney tissue by measuring kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-Dglucosaminidase (NAG), liver-type fatty acid binding protein (LFABP) expression. Material and methods: We enrolled thirty consecutive patients (Group 1) who underwent RIRS that presented with renal calculi size <2 cm. Forty-seven control patients (Group 2) with no signs or symptoms of urogenital disease were also enrolled for this study. Patients urine KIM-1, NGAL, NAG, and LFABP and creatinine levels were determined before the surgery, 2 hours after the surgery, and 24 hours after the surgery. Results: Demographic data were established and found to be similar between the two groups. Two hours after the surgery KIM-1/Cr and NGAL/Cr levels had increased significantly in urine compared to levels before the surgery (P:0.04, P:0.02 respectively) and decreased 24 hours after the surgery. The NAG/Cr and LFABP/Cr levels did not change significantly after the surgery. Conclusion: According to acute kidney injury (AKI) markers, this study is suggests that RIRS is a safe method, KIM-1/Cr and NGAL/Cr levels were increased first 2 hours but returned to initial levels within 24 hours after the surgery.eninfo:eu-repo/semantics/closedAccessRetrograde Intra-Renal SurgeryAcute Kidney InjuryKidney Injury Molecule-1Neutrophil Gelatinase-Associated LipocalinN-Acetyl-Beta-D-GlucosaminidaseArticle8581478152WOS:00035929320018326221383Q4