Yıldırım, Halil CumhurKupik, Gülnihan ErenMustafayev, Teuta ZotoBerber, TanjuYavuz, BerrinÇetinayak, OğuzTeke, Fatma2023-10-172023-10-172023Yıldırım, H. C., Kupik, G. E., Mustafayev, T. Z., Berber, T., Yavuz, B., Çetinayak, O. ve diğerleri. (2023). A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001). Head and Neck, 45(5), 1194-1205.1043-3074https://onlinelibrary.wiley.com/doi/10.1002/hed.27333https://hdl.handle.net/11468/12825Background: We aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. Methods: In a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. Results: Median age was 48 (9–83), age distribution was bimodal, 74.1% were male, and 78.7% were stage III-IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6–78) months follow-up, 8.2% locoregional and 8% distant relapse were observed. Three-year overall survival was 89.5% and was lower in patients with age ≥50, male sex, keratinizing histology, T4, N3 and advanced stage (III-IVA). Conclusions: Patients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.eninfo:eu-repo/semantics/openAccessChemoradiotherapyEBV-DNAIntensity-modulated radiotherapyNasopharyngeal carcinomaNonendemicArticle45511941205WOS:0009407685000012-s2.0-851492692383685487310.1002/hed.27333Q1N/A