Yılmaz, Mustafa AbdullahÇakır, Oğuzİzol, EbubekirTarhan, AbbasBehçet, Lütfi̇Zengin, Gökhan2024-03-182024-03-182023Yılmaz, M. A., Çakır, O., İzol, E., Tarhan, A., Behçet, L. ve Zengin, G. (2023). Detailed phytochemical evaluation of a locally endemic species (Campanula baskilensis) by LC-MS/MS and its in-depth antioxidant and enzyme inhibitory activities. Chemistry and Biodiversity, 20(12), 1-14.1612-1872https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.202301182https://hdl.handle.net/11468/13599The importance of bioactive plant species in the scientific world is increasing day by day. The relationship between health and traditional-modern life, promotes the creation of new value-added natural products. This is the first research to conduct a bioactivity and chemical composition analysis of Campanula baskilensis species, which belongs to the medicinally important genus Campanula L (Campanulaceae). The aim of the current study is to quantitatively investigate the phytochemical contents of aerial and root parts of different C. baskilensis extracts (ethanol, methanol, and water) by LC-MS/MS and to evaluate their total phenolic and flavonoid contents, antioxidant and enzyme inhibitory activities. Remarkably, LC-MS/MS results revealed that, high amounts of quinic acid (53.6 mg/g aerial-MeOH extract), fumaric acid (6.3 mg/g aerial-H2O extract, 2.5 mg/g root-H2O extract), protocatechuic acid (11.4 mg/g aerial-H2O extract), vanillic acid (1.4 mg/g aerial-EtOH extract), quercetin-3-O-rutinoside (rutin) (2.3 mg/g aerial-EtOH extract), hesperetin 7-rutinoside (hesperidin) (2.0 mg/g aerial-EtOH extract), kaempferol-3-O-rutinoside (nicotiflorin) (5.5 mg/g aerial-EtOH extract) were detected in the extracts of the species. Considering the bioactivity tests performed on C. baskilensis extracts, aerial-H2O extract showed significant activity in all antioxidant assays. However, ethanol extracts of root and aerial parts exhibited the highest activities in all enzyme inhibitory tests.eninfo:eu-repo/semantics/closedAccessAntioxidantBioactivityCampanula baskilensisEnzyme inhibitionLC-MS/MSArticle2012114WOS:0011075440000012-s2.0-851770578043784649610.1002/cbdv.202301182Q3N/A