Kaplan, Muhammet AliKüçüköner, Mehmetİnal, AliUrakçı, ZuhatEvliyaoǧlu, OsmanFırat, UǧurKaya, MuhsinIşıkdoǧan, Abdurrahman2024-04-242024-04-242014Kaplan, M. A., Küçüköner, M., İnal, A., Urakçı, Z., Evliyaoǧlu, O., Fırat, U. ve diğerleri. (2014). Relationship between serum soluble vascular adhesion protein-1 level and gastric cancer prognosis. Oncology Research and Treatment, 37(6), 340-344.2296-5270https://doi.org/10.1159/000362626https://hdl.handle.net/11468/23551Background: Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion in a sialic acid-dependent manner. The prognostic importance of VAP-1 was determined in various human cancers. The aim of this study was to determine the relationship between VAP-1 and prognosis of gastric cancer. Materials and Methods: Serum of operable and metastatic gastric cancer patients was collected before treatment (surgery, radiotherapy, and/or chemotherapy). VAP-1 levels were measured by enzyme-linked immunosorbent assay. Results: A total of 86 gastric cancer patients (32 female, 54 male) were included in the study. Curative surgical treatment was performed in 54 (62.8%) patients. The mean serum VAP-1 level was 324.4 pg/ml and significantly higher in operable gastric cancer patients compared to metastatic gastric cancer patients (383.1 ± 173.5 vs. 225.2 ± 113.9 pg/ml; p < 0.001). When a cut-off value for VAP-1 of 218.8 pg/ml was determined by receiver operating characteristic (ROC) curves for presence of metastasis, sensitivity and specificity were 81.5 and 65.6%, respectively. Patients with decreased VAP-1 levels had a significantly poorer prognosis compared to patients with increased serum VAP-1 levels (median survival 8.2 vs. 23.5 months; p < 0.001). Multivariate analysis showed that VAP-1 is an independent prognostic factor of gastric cancer (odds ratio 2.3, 95% confidence interval 1.1-4.9; p = 0.032). Conclusion: A low serum VAP-1 level may be an indicator of poor prognosis in gastric cancer. This study demonstrated that low serum VAP-1 levels are associated with poor prognosis in gastric cancer patients.eninfo:eu-repo/semantics/closedAccessGastric cancerPrognosisVascular adhesion protein-1Article3763403442-s2.0-849022722192490376510.1159/000362626Q3