Araç, SongülKarahan, Mehmet ZülkifÖzel, MehmetYiğit, RamazanAkkoç, HasanAraç, Eşref2025-03-082025-03-0820212602-2079https://doi.org/10.28982/josam.843042https://hdl.handle.net/11468/31526Background/Aim: The common cardiac toxicities of hydroxychloroquine (HCQ) and azithromycin (AZ) are not well defined in COVID-19 patients. Index of cardiac electrophysiological balance (iCEB) is used as a novel risk marker for drug-induced arrhythmias. The purpose of this study was to evaluate ventricular repolarization using iCEB and other conventional ECG parameters such as the end of electrocardiographic T wave (Tp-e) interval, Tp-e/QT ratio, and Tp-e/ heart rate-corrected QT (QTc) ratio in COVID-19 patients treated with HCQ and AZ. Methods: This retrospective study enrolled 164 patients diagnosed with COVID-19 pneumonia in the Emergency Department (ED) and then transferred to the ward or the intensive care unit in April 2020. Results: A total of 164 patients with a mean age of 47 (18) years (range: 18-97 years) included 83 (50.6%) females. There were 38 and 126 patients in Groups HTQ and HTQ+AZ, respectively. On the 5th day of hospitalization, all patients’ heart rates were significantly lower (Peninfo:eu-repo/semantics/openAccessCOVID-19HydroxychloroquineAzithromycinECGiCEBTp-e intervalArticle5541241610.28982/josam.843042