Bekçibaşı, MuhammedDeveci, ÖzcanOğuz, AbdullahBozkurt, FatmaDayan, SaimÇelen, Mustafa Kemal2022-08-192022-08-192021Bekçibaşı, M., Deveci, Ö., Oguz, A., Bozkurt, F., Dayan, S. ve Çelen, M.K. (2021). Serum TNF-alpha, IL-1 beta, and IL-6 levels in chronic HBV-infected patients. International Journal of Clinical Practice, 75(8), 1-4. https://doi.org/10.1111/ijcp.142921742-1241https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijcp.142921368-5031https://hdl.handle.net/11468/10214WOS:000649785600001PMID: 33930244Background The objective of the study was to evaluate the serum levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 in chronic HBV-infected patients. Methods The present study was a single centre, prospective and randomised controlled trial. Twenty healthy volunteers and thirty HBeAg-negative patients with planned liver biopsy and treatment-naive diagnosed with chronic hepatitis B (CHB) were included in the study. TNF-alpha, IL-1 beta and IL-6 levels were measured in the serum of CHB patient and control groups using an ELISA. Results were compared statistically using a Mann-Whitney U test. Results The mean age of the CHB group (20 men, 10 women) and the control group (10 men, 10 women) was 33.3 +/- 9.7 (17-55) and 26.1 +/- 12.3 (16-57), respectively. When the two groups were compared with the Mann-Whitney U-test, TNF-alpha and IL-6 levels were found to be significantly higher in the CHB group compared to the control group (P = .003, P < .0001, respectively). Although IL-1 beta levels were not statistically significant, they were higher in the CHB group compared to the controls (P = .07). Conclusions The results of our study showed that serum levels of TNF-alpha and IL-6 are increased in CHB patients.eninfo:eu-repo/semantics/embargoedAccessChronic Hepatitis-BArticle75814WOS:0006497856000012-s2.0-851056682413393024410.1111/ijcp.14292Q1Q2