Varol, SeferAkil, EsrefYunce, MuharremKaplan, BrahimOzdemir, Hasan HuseyinArslan, DemetYilmaz, Ahmet2024-04-242024-04-2420150393-63842283-9720https://hdl.handle.net/11468/22310The pathogenesis of migraine has been well studied and it is associated with oxidative stress, neurogenic inflammation, and endothelial dysfunction. To the best of our knowledge, no studies have focused on the impact of the parathormone (PTH) and homocysteine levels in migrane patients. To determine migraine-stroke association, our study focused on the levels of PTH and homocysteine in the blood of migraine patients. Fifty five migraine patients in the presence or absence of aura were included. The patients in the migraine group were divided into subgroups: (I) migraine in the attack period (with and without aura) (n = 23), and (II) migraine in the interictal period (with and without aura) (n = 32). As a control, 30 healthy volunteers were also enrolled in the study. As a result, we found that PTH and homocysteine levels of the migraine patients were increased significantly when compared with healthy volunteers (p = 0.001). The PTH and homocysteine levels of the patients with aura were higher than patients without aura in the migraine group (p < 0.05). There were no statistically significant differences between PTHIhomocysteine levels and migraine duration or migraine attack frequency (p > 0.05). There was a positive correlation between PTH and homocysteine levels in the migraine patients (p = 0.001, r = 0.49). To summarize, we found statistically significant increases in PTH and homocysteine blood levels of migraine patients versus healthy volunteers. These results may help to understand the pathogenesis of migraine ischemia, and potentially identify new prognostic markers for this condition.eninfo:eu-repo/semantics/closedAccessMigrainePathogenesisParathyroid HormoneHomocysteineArticle313729733WOS:000357001100029Q4