Beceriklisoy, H. B.Ozyurtlu, N.Kaya, D.Handler, J.Aslan, S.2024-04-242024-04-2420080043-535Xhttps://hdl.handle.net/11468/20781The aim of this study was to investigate the effectiveness of Thuja occidentalis and Urtica urens in pseudopregnant bitches. Clinically pseudopregnant bitches (n=38) were assigned per random to groups as follows: Group I: Thuja occidentalis D30 (8 globules, 3 times a day, per os, n=15); Group II: Urtica urens D6 (8 globules, 3 times a day, per os, n=15); Group III: naloxone (control group, 0.01 mg/kg, twice daily, s.c., n=8). Treatments were continued until clinical signs resolved. Animals were classified as no, mild, moderate, and severe (score -, +, ++, and +++) according to the clinical signs of mammary glands and behavioural signs during the study. Bitches were examined at 3-5 days intervals by means of adspection and palpation until clinical signs resolved. Successful recovery rates (100 %) were found in Group I and II. Application of naloxone was found to be successful in only 3 of 8 bitches (37.5 %). Mean duration of treatments in Group I, II and III was 11.6 +/- 4.6 (min-max: 3-18) days, 13.5 +/- 3.7 (min-max: 6-19) days and 14.3 +/- 5.9 (min-max: 10-21) days, respectively. During treatment with Thuja occidentalis D30 and Urtica urens D6, the percentages of bitches with behavioural problems significantly decreased within 3-5 days from 33.3 % to 6.7 % (p=0.033) and from 66.7 % to 33.3 % (p=0.050), respectively. All bitches treated with Thuja occidentalis D30 or Urtica urens D6 showed normal behaviour within 10 days after onset of treatments but 2 bitches in the naloxone group kept showing behavioural signs until Days 15-20 of treatment. Concerning mammary gland scores, treatments yielded significantly higher success rates in Group I and Group II (100 in both groups) compared to the success rate observed in Group III (37.5 %; p=0.012). No side effects were observed during the study. In conclusion, the homeopathic agents Thuja occidentalis D30 and Urtica urens D6 proved to be effective and safe in pseudopregnant bitches.eninfo:eu-repo/semantics/closedAccessBitchHomeopathyPseudopregnancyThuja OccidentalisUrtica UrensArticle9511-12263268WOS:0002619060000032-s2.0-57749180459Q4Q4