Demir, BulentGuven, SuleymanGuven, Emine Seda GuvendagAtamer, YildizGul, Talip2024-04-242024-04-2420091046-7408https://doi.org/10.1111/j.1600-0897.2009.00734.xhttps://hdl.handle.net/11468/17643Problem The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects. Method of study Serum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study. Results The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups. Conclusion Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.eninfo:eu-repo/semantics/openAccessIl-6PathophysiologySerum LevelTnf-AlphaUnexplained InfertilityArticle624261267WOS:0002697418000072-s2.0-703499818801970602210.1111/j.1600-0897.2009.00734.xQ1Q3