Yilmaz, ZulfukarYildirim, YasarAydin, Fatma YilmazAydin, EmreKadiroglu, Ali KemalYilmaz, Mehmet Emin2024-04-242024-04-2420130393-63842283-9720https://hdl.handle.net/11468/21688Introduction: Accurate and sensitive methods are very important for the assessment of volume status in chronic kidney disease (CKD). Bioelectrical impedance analysis (BIA) is a simple, non-invasive and promising method to assess volume status in patients with CKD. Objective: The aim of this study was to evaluate the association between BIA derived relative hydration status (RHS) and clinical findings and other markers of volume status in patients who were newly diagnosed with stage 5 CKD. Patients and method: Totally 85 patients who were newly diagnosed with stage 5 CKD and have not received any renal replacement therapy were enrolled in this study. Hydration status was assessed by multi-frequency BIA device (Body Composition Monitor, Fresenius). Relative hydration status was defined as the overhydration (OH) to extracellular water (ECW) ratio and clinical overhydration was considered as an overhydration-to-extracellular water ratio of >% 15. The patient population was divided into 2 groups; group 1: RHS >% 15, group 2: RHS <= %15. Inferior vena cava (IVC) diameter was measured by echocardiography and indexed for body surface area as IVC index (mm/m2). NT-proBNP was measured by immunoassay. Results: Among subjects, 57.6% of the patients had RHS >% 15. Systolic blood pressure (SBP), diastolic blood pressure (DBP), proteinuria, OH. ECW, IVC index, and NT-proBNP were significantly higher, while serum albumin and residual urine were significantly lower in group I than group 2 (p<0.05). There was a significant positive correlation between RHS and SBP, DBP, proteinuria. OH, ECW, NT-proBNP and IVC index and a negative correlation with albumin and residual urine (p<0.05). Conclusions: RHS may be an important measuring parameter of volume overload in patients with CKD. RHS is correlated with NT-proBNP, blood pressure and IVC index.eninfo:eu-repo/semantics/closedAccessBioelectrical Impedance AnalysisRelative Hydration StatusIvc IndexNt-ProbnpBlood PressureArticle294869874WOS:000330151200044Q4