Kasumov, V. T.Suzergoz, F.Sahin, E.Celik, O.Aslanoglu, M.2024-04-242024-04-2420140022-11391873-3328https://doi.org/10.1016/j.jfluchem.2014.03.011https://hdl.handle.net/11468/15642A series of new polyfluorinated bis(N-C(6)F(n)H(5-n)3,5-(t)Bu2salicylaidiminato)Cu(11) [n = 2; 2,4-F2C6H3-3,5-DTBS (1), 2,5-F2C6H3-3,5-DTBS (2), 2,6-F2C6H3-3,5-DTBS (3); n = 3; 2,3,4-F3C6H2-3,5-DTBS (4), n= 4; 2,3,5,6-F4C6H-3,5-DTBS (5), n = 5; 2,3,4,5,6-F5C6-3,5-DTBS (6); where 3,5-DTBS is 3,5-(t)Bu(2)salicylaldiminatol with N-polyfluoropheny1-3,5-di-tert-butylsalicylaldi-mines (HL1-HL6) have been synthesized. Their structure, chemical and electrochemical redox-reactivity as well as cytotoxic activity of these compounds were characterized by analytical, spectroscopic (UV/vis, FT-IR, F-19 NMR and EPR), magnetic, CV techniques and MIT assay. The in situ UV/Vis study have shown that the redox behavior of 1-6 and their Cu-phenoxyl radicals (1(center dot+)-6(center dot+) and 1(center dot center dot+)-6(center dot center dot+)) depend on the number and positions of F atoms on the aniline ring as well as of the nature of solvent. The in vitro cytotoxic activity studies of HL1-HL6 and 1-6 against K562 cell lines indicate that the HL1, HL4-HL6 and their corresponding complexes (1, 4-6) exhibited higher cytotoxic activity than HL2, HL3 and their complexes. Compounds 1, 4 and 5 are more cytotoxic than their respective ligands. (C) 2014 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessPolyfluorinatedCu(Ii)-Phenoxyl RadicalsSpectroscopyAnticancerArticle1627889WOS:0003368270000112-s2.0-8489954765810.1016/j.jfluchem.2014.03.011Q2Q2