Turkoglu, AhmetGul, MesutYuksel, Hatice KurtAlabalik, UlasUlger, Burak VeliUslukaya, OmerAvci, Yahya2024-04-242024-04-2420151011-75711423-0151https://doi.org/10.1159/000369020https://hdl.handle.net/11468/17983Objective: The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model. Materials and Methods: Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined. Results: There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 +/- 11.8 mu g/mg) and the curcumin (63.8 +/- 13.9 mu g/mg) group compared to the control group (85.7 +/- 22.1 mu g/mg; p < 0.05). Conclusion: These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation. (C) 2014 S. Karger AG, Baseleninfo:eu-repo/semantics/openAccessCurcuminIntraperitoneal AdhesionAdhesion FormationArticle242153158WOS:0003496943000082-s2.0-849235537762550414010.1159/000369020Q1Q3