Yıldızhan, EdaÖzesmer, Hikmetİnan, Mazlum M.Tatlı, FarukRençber, M.Akbaş, A.Kamar, M.2023-10-252023-10-252023Yıldızhan, E., Özesmer, H., İnan, M. M., Tatlı, F., Rençber, M., Akbaş, A. ve diğerleri. (2023). Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats. Polish Journal of Veterinary Sciences, 26(3), 343-347.2300-2557https://journals.pan.pl/dlibra/publication/145038/edition/128500/contenthttps://hdl.handle.net/11468/12944The aim of this study is to determine the protective efficacy of anise in cerebral ischemia and reperfusion injury in rats. In this study, 28 Wistar Albino rats, weighing 250-300 grams (g), were used. Four groups were formed with 7 rats in each group. Group 1 (n=7): Control group, Group 2 (n=7): Anise group, 5 mL/kg/day of anise aqueous extract prepared according to Gamberini’s protocol was given orally by gavage for 30 days. Group 3 (n=7): Cerebral ischemia reperfusion (CIR) group, at the beginning of the experiment, 30 minutes of cerebral ischemia and 1 hour of reperfusion were induced and the animals were sacrificed by exanguination. Group 4 (n=7): Anise+ CIR group, After administering 30 days of anise’s aqueous extract, CIR was induced and the study was terminated. TOS values of the Anise+ CIR group was significantly lower than that of the CIR group (p<0.05). Il-6 and TNF-α values of the CIR group were significantly higher than the Anise+ CIR group (p<0,05). Our study revealed that anise ameliorates oxidative damage and inflammation due to cerebral ischemia/reperfusion, by reducing the levels of inflammatory cytokines (TNF-α, Il-6).eninfo:eu-repo/semantics/embargoedAccessAniseCerebral ischemia reperfusionOxidative stressInflammationArticle263343347WOS:0010763536000022-s2.0-851719007433772703510.24425/pjvs.2023.145038Q3N/A