Türkçü, G.Avcı, Y.Evliyaoğlu, O.Gökalp, O.Gümüş, M.Tanrıkulu, A. C.Abakay, A.Büyükbayram, H.Fırat, U.2022-12-212022-12-212021Türkçü, G., Avcı, Y., Evliyaoğlu, O., Gökalp, O., Gümüş, M., Tanrıkulu, A.C. ve diğerleri. (2021). Protective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injury. West Indian Medical Journal, 69(5), 350-355.2309-58300043-3144https://www.mona.uwi.edu/fms/wimj/article/2815https://hdl.handle.net/11468/11096Objective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage. Methods: Eighty adult rats were randomly divided into eight groups: control, INH, RFP, INII+RFP, INII+CAPE, RFP+CAPE, INII+RFP+CAPE, and CAPE. Both _MI and RFP were orally administered for 30 days at a dose of 50 mg/kg/day. Caffeic acid phenethyl ester was intraperitoneally injected for 30 days (10 mu mol/kg). Blood samples, hepatic and pancreatic tissues were obtained on day 30. Results: Total oxidant status levels were significantly higher in MI and/or RFP-treated groups than those of control and CAPE groups, while total antioxidant status and paraoxonase levels were significantly reduced in INH-RFP groups compared with the group receiving CAPE. Histopathological deterioration was observed in RFP and INH groups in pancreatic and hepatic tissue. However, significant amelioration was observed in CAPE-treated groups. Conclusion: Our findings suggest that CAPE may be a promising agent to prevent the side effects of INH and RFP treatment on hepatic and pancreatic tissues.eninfo:eu-repo/semantics/closedAccessCaffeic acid phenethyl esterIsoniazidLiverPancreasRifampicinArticle695350355WOS:0007196410000162-s2.0-8512207669310.7727/wimj.2015.561Q4Q4