Karahan, M.Kılıç, D.Güven, S.2022-07-072022-07-072021Karahan, M., Kılıç, D.ve Güven, S. (2021). Systemic inflammation in both open-angle and angle-closure glaucoma: role of platelet-to-lymphocyte ratio. Bratislava Medical Journal- Bratislavske Lekarske Listy, 122(1), 45-48. http://doi.org/10.4149/BLL_2021_0050006-92481336-0345http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7057&category_id=171&option=com_virtuemart&vmcchk=1&Itemid=1https://hdl.handle.net/11468/10144WOS:000637614800006PMID: 33393320AIM: To analyse the effect of systemic infl ammatory status in patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) by calculating platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). METHODS: This retrospective case-control study included 200 patients with POAG, 22 patients with PACG and 100 healthy subjects. The participants' white-blood-cell, lymphocyte, neutrophil, and platelet counts were recorded from previous blood assays. NLR and PLR were calculated manually. Results were compared among the groups. RESULTS: Both the POAG and PACG groups had higher platelet counts and PLR values than the control group (p=0.001 and p=0.001; respectively). The difference in NLR between POAG, PACG and control groups was not statistically signifi cant (p=0.076). The POAG group had higher NLR values than the control (p=0.035). CONCLUSION: Both the POAG and the PACG groups exhibited higher platelet and PLR levels than the control. These results indicate a potential role of systemic infl ammation in the pathogenesis of POAG and PACG (Tab. 4, Fig. 1, Ref. 35). Text in PDF www.elis.skeninfo:eu-repo/semantics/openAccessNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte-ratioPrimary open-angle glaucomaPrimary angle-closure glaucomaSystemic inflammationArticle12214548WOS:0006376148000062-s2.0-850992711903339332010.4149/BLL_2021_005Q2Q4