Sak, Muhammet ErdalSoydinc, Hatice EnderSak, SibelEvsen, Mehmet SiddikAlabalik, UlasAkdemir, FatihGul, Talip2024-04-242024-04-2420131743-91911743-9159https://doi.org/10.1016/j.ijsu.2013.06.007https://hdl.handle.net/11468/15523Background: To evaluate the protective effects of curcumin in experimental ischemia and ischemia/reperfusion (I/R) injury of rat ovaries. Methods: Forty-eight female adult Wistar Albino rats were used. Rats divided into six groups and designed: Sham, Torsion, Detorsion, Sham + Curcumin, Torsion + Curcumin, and Detorsion + Curcumin. Except for the Sham and Sham + Curcumin group, all groups were performed to bilateral adnexal torsion for 3 h. Bilateral adnexal detorsion was implemented in the Detorsion and Detorsion + Curcumin groups. The injection of curcumin was intraperitoneally achieved 30 min before the sham, torsion and detorsion. Results: Total oxidant status levels (TOS), oxidative stress index (OSI) and histologic scores values of ovarian tissue were higher in the torsion and detorsion groups than the sham group (p < 0.05). There was a strong correlation between the total histologic scores of I/R injury and the OSI (r = 0.809, p < 0.001). By the use of curcumin, a significant decrease was established in the mean levels of oxidant markers and histopathologic scores of the ovarian tissues. Conclusions: Administration of curcumin is effective in reversing tissue damage induced by ischemia-reperfusion injury in ovarian torsion. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/openAccessAdnexial TorsionCurcuminOxidative StressRatArticle119967970WOS:0003269772000452-s2.0-848872005882379644710.1016/j.ijsu.2013.06.007Q1Q2