Effects of electroporation on anticancer activity of 5-FU and newly synthesized zinc(II) complex in chemotherapy-resistance human brain tumor cells

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dc.authorid0000-0001-6160-5626en_US
dc.contributor.authorAlkış, Mehmet Eşref
dc.contributor.authorTuran, Nevin
dc.contributor.authorAlan, Yusuf
dc.contributor.authorKandemir, Sevgi İrtegün
dc.contributor.authorBuldurun, Kenan
dc.date.accessioned2021-10-01T09:08:24Z
dc.date.available2021-10-01T09:08:24Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000698397100001
dc.descriptionPMID: 34550481
dc.description.abstractZn(II) complex of Schiff base derived from the condensation of 4-aminopyrimidine-2(1H)-one with salicylaldehyde was prepared and characterized by various physico-chemical and spectral methods for structure determination. The cytotoxic activity of the Zn(II) complex was investigated in comparison with 5-fluorouracil (5-FU) against two different human brain tumor cell lines (T98G and U118), while primer human dermal fibroblast cells (HDF) was used as control for biocompatibility. Then, the effectiveness of electroporation (EP) on cytotoxic activities of these compounds has been examined. The cytotoxicities of the 5-FU and new Zn(II) complex, alone or in combination with electroporation, were determined by MTT assay. The Zn(II) complex showed good cytotoxicity against T98G and U118 brain tumor cell lines with IC50 = 282.47 and 297.91 mu M respectively, while it was safe on HDF healthy cells with IC50 = 826.72 mu M. The 5-FU exhibited less cytotoxicity compared to the Zn(II) complex against T98G (IC50 = 382.35 mu M) and U118 (IC50 = 396.56 mu M) tumor cell lines. The combined application of Zn (II) + EP decreased the IC50 value by 5.96-fold in T98G cells and 4.76-fold in U118 cells. EP showed a similar effect in its combined application with 5-FU, resulting in a decrease of the IC50 value of 4.22-fold in the T98G cells and 3.84-fold in the U118 cells. In a conclusion, the Zn(II) complex exhibited an anticancer potential against both brain tumor cell lines (T98G and U118) and EP greatly increased the cytotoxicity of Zn(II) complex and 5-FU on these chemotherapy-resistant cells.en_US
dc.identifier.citationAlkış, M.E., Turan, N., Alan, Y., Kandemir, S.I. ve Buldurun, K. (2021). Effects of electroporation on anticancer activity of 5-FU and newly synthesized zinc(II) complex in chemotherapy-resistance human brain tumor cells. Medical Oncology, 38(11), 1-18.en_US
dc.identifier.doi10.1007/s12032-021-01579-7
dc.identifier.endpage18en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue11en_US
dc.identifier.pmid34550481
dc.identifier.scopus2-s2.0-85115254374
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://assets.researchsquare.com/files/rs-649109/v1/79899ad9-64f0-4603-bc1c-ea454b052e9b.pdf?c=1632407360
dc.identifier.urihttps://hdl.handle.net/11468/7855
dc.identifier.volume38en_US
dc.identifier.wosWOS:000698397100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKandemir, Sevgi İrtegün
dc.language.isoenen_US
dc.publisherHumana Press INCen_US
dc.relation.ispartofMedical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZn(II) complexen_US
dc.subject5-Fluorouracilen_US
dc.subjectElectrochemotherapyen_US
dc.subjectAnticancer activityen_US
dc.subjectSpectral techniquesen_US
dc.titleEffects of electroporation on anticancer activity of 5-FU and newly synthesized zinc(II) complex in chemotherapy-resistance human brain tumor cellsen_US
dc.titleEffects of electroporation on anticancer activity of 5-FU and newly synthesized zinc(II) complex in chemotherapy-resistance human brain tumor cells
dc.typeArticleen_US

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