Antiglycative effect of combination of extracts of capsicum annuum (chilli) and pyridoxamine against glycation in streptozotocin-induced experimental diabetes in rats

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dc.authorid0000-0003-0363-6488en_US
dc.authorid0000-0002-1075-926Xen_US
dc.authorid0000-0002-5616-8625en_US
dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0001-9603-0631en_US
dc.authorid0000-0003-3362-1797en_US
dc.contributor.authorİnceören, Nesrin
dc.contributor.authorAkay, Feryal
dc.contributor.authorNas, Cemal
dc.contributor.authorDeveci, Engin
dc.contributor.authorKızıl, Göksel
dc.contributor.authorKızıl, Murat
dc.date.accessioned2023-09-21T06:11:49Z
dc.date.available2023-09-21T06:11:49Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractGlycation causes the formation of advanced glycation end products, which play an important role in the pathogenesis of diabetic complications, which alter changes the structure and functional properties of proteins that negatively afect cellular metabolism. In the current study, we investigated benefcial efects of red chili pepper extract and capsaicin, the main bitter ingredient in red peppers and pyridoxamine, a vitamin B6, one by one or in combination on glycation and advanced glycation end products damage in streptozotocin-induced diabetic rats. The total amount of capcaicin in red chili pepper extract was found to be 3.51 mg/g DW by HPLC. Male Sprague Dawley rats (8 weeks old), weighing 200–300 g, were divided into 12 groups of 8 rats each. A single dose of streptozotocin (50 mg/kg body weight) was administered to induce experimental diabetes in rats. Group 1 was normal control, group 2 was diabetic control. Groups 3 and 4, 200 and 400 mg/kg red chili pepper extract, groups 5 and 6, 6 and 8 mg/kg capsaicin and group 7, 4 mg/ml pyridoxamine and group 8 were receiving 300 mg/kg metformin. Groups 9 and 10, 200 and 400 mg/kg red chili pepper extract+4 mg/ml PM and groups 11 and 12 were diabetic rats treated with 6 and 8 mg/kg capsaicin+4 mg/ml pyridoxamine. Oral treatment with intragastric tube was administered every day for 28 days. At the end of the experiment, subjects in all groups were given anesthesia once and the rib cage was performed by intracardiac intervention and blood was collected. Immediately, the liver and kidneys were grossly removed for histological examination. The results of our study showed that the combined doses of red chili pepper extract+pyridoxamine and capsaicin+pyridoxamine signifcantly reduced blood glucose levels, serum uric acid, urea, creatinine, AST, ALT, ALP, LDH, total cholesterol, fructosamine, HbA1c levels and signifcantly increased serum HDL and insulin levels. At the same time, histopathological studies also strongly supported the anti-diabetic, hepatoprotective and renoprotective efects of these combination doses.en_US
dc.identifier.citationİnceören, N., Akal, F., Nas, C., Deveci, E., Kızıl, G. ve Kızıl, M. (2023). Antiglycative effect of combination of extracts of capsicum annuum (chilli) and pyridoxamine against glycation in streptozotocin-induced experimental diabetes in rats. Revista Brasileira de Farmacognosia, 33(4), 831-846.en_US
dc.identifier.doi10.1007/s43450-023-00414-6
dc.identifier.endpage846en_US
dc.identifier.issn1981-528X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85162122579
dc.identifier.scopusqualityQ2
dc.identifier.startpage831en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s43450-023-00414-6
dc.identifier.urihttps://hdl.handle.net/11468/12575
dc.identifier.volume33en_US
dc.identifier.wosWOS:001014959700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorİnceören, Nesrin
dc.institutionauthorAkal, Feryal
dc.institutionauthorDeveci, Engin
dc.institutionauthorKızıl, Göksel
dc.institutionauthorKızıl, Murat
dc.language.isoenen_US
dc.publisherSpringer Science and Business Mediaen_US
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectAdvanced glycation end productsen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectRed chili pepper extracten_US
dc.subjectPyridoxamineen_US
dc.subjectCapsaicinen_US
dc.titleAntiglycative effect of combination of extracts of capsicum annuum (chilli) and pyridoxamine against glycation in streptozotocin-induced experimental diabetes in ratsen_US
dc.titleAntiglycative effect of combination of extracts of capsicum annuum (chilli) and pyridoxamine against glycation in streptozotocin-induced experimental diabetes in rats
dc.typeArticleen_US

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