Effects of modulation factors in breast cancer treatment with helical tomotherapy

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dc.authorid0000-0003-3279-2842en_US
dc.contributor.authorZincircioğlu, S. B.
dc.contributor.authorDoğan, M. H.
dc.date.accessioned2022-08-22T12:16:09Z
dc.date.available2022-08-22T12:16:09Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalıen_US
dc.descriptionWOS:000649198300002
dc.description.abstractBackground: The aim of this study was to compare the dosimetric values of TomoHelical (TH) plans using modulation factors 3 and 5 in patients with breast cancer. Materials and Methods: Two different radiotherapy treatment plans, including modulation factors 3 and 5, were generated retrospectively for 12 consecutive intact breast cancer patients. Twelve different plans in terms of the modulation factor were generated. Other optimization parameters (i.e., pitch and field width) were the same for all plans. Results: No differences were found between the conformity index (CI) and homogeneity index (HI) values of both plans (p>0.05). The values of D mean, V5, and V20 of the ipsilateral lung in the TomoHelical plan with modulation factor 5 (TH5) were significantly lower than with modulation factor 3 (TH3) for all 12 patients (4.9 Gy, 20.14%, 3.23%. Vs, 10.95 Gy, 58.9%, 18.7%; p=0.01, p=0.00, p=0.002, respectively). Also, the values of Dmean and V5 of the heart in TH5 were significantly lower than in TH3 (6.45 Gy, 34.33%, vs. 7.12 Gy, 64.22%; p=0.004, p=0.00, respectively). Conclusion: Both the TH5 and TH3 plans provided adequate coverage of the intact breast. TH5 delivered a decreased dose to the ipsilateral organs at risk (OARs), especially in the lung and heart volume, which is the main cause of long-term toxicity. The novelty of this work is the obvious reduction in same-sided lung volume irradiation by increasing the modulation factor.en_US
dc.identifier.citationZincircioğlu, S. B. ve Doğan, M. H. (2021). Effects of modulation factors in breast cancer treatment with helical tomotherapy. International Journal Radiation Research, 19(2), 251-257. https://doi.org/10.18869/acadpub.ijrr.19.2.251en_US
dc.identifier.doi10.18869/acadpub.ijrr.19.2.251
dc.identifier.endpage257en_US
dc.identifier.issn2322-3243
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85106636885
dc.identifier.scopusqualityQ4
dc.identifier.startpage251en_US
dc.identifier.urihttp://ijrr.com/article-1-3639-en.html
dc.identifier.urihttps://hdl.handle.net/11468/10231
dc.identifier.volume19en_US
dc.identifier.wosWOS:000649198300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZincircioğlu, S.B.
dc.institutionauthorDoğan, M.H.
dc.language.isoenen_US
dc.publisherIJRR-Iranian Journal Radiation Researchen_US
dc.relation.ispartofInternational Journal Radiation Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast canceren_US
dc.subjectModulation factoren_US
dc.subjectIrradiationen_US
dc.titleEffects of modulation factors in breast cancer treatment with helical tomotherapyen_US
dc.titleEffects of modulation factors in breast cancer treatment with helical tomotherapy
dc.typeArticleen_US

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