Single injection of triamcinolone versus three repeated injections of bevacizumab for treatment of diabetic macular edema
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
To compare the effect of a single intravitreal injection of triamcinolone acetonide versus three consecutive monthly intravitreal injections of bevacizumab for the treatment of diabetic macular edema (DME). Forty patients treated with a single intravitreal injection of 4 mg triamcinolone acetonide (triamcinolone group) were compared with 40 patients treated with three consecutive monthly intravitreal injections of 1.25 mg bevacizumab (bevacizumab group). The triamcinolone group showed a significant decrease in mean central retinal thickness (CRT) from 472.5 ?m ± 120.35 to 374.0 ?m ± 152.31 after 3 months (p < 0.001). The bevacizumab group also showed a significant reduction in CRT from 464.5 ?m ± 115.3 to 370.0 ?m ± 142.31 (p < 0.001). The triamcinolone group displayed an increase in best-corrected visual acuity (BCVA) following a single intravitreal triamcinolone acetonide injection from a mean of +0.70 ± 0.17 logMAR to a mean of +0.54 ± 0.38 logMAR after 3 months (p < 0.05). The bevacizumab group also showed an increase in BCVA following three injections of bevacizumab from a mean of +0.73 ± 0.28 logMAR to a mean of +0.57 ± 0.33 logMAR (p < 0.05). Statistical analysis showed no significant difference between both groups at 3 months. Our study showed that a single intravitreal injection of triamcinolone is as effective as three consecutive monthly intravitreal injections of bevacizumab for treatment of DME with regard to BCVA and CRT measured by optical coherence tomography. Despite the recent popularity of bevacizumab, three injections are no more effective than a single injection of triamcinolone for the treatment of DME.
Açıklama
Anahtar Kelimeler
Bevacizumab, Diabetic macular edema, Intravitreal injection, Triamcinolone
Kaynak
International Ophthalmology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
33
Sayı
4
Künye
Taş, M., Öner, V., Alakuş, M. F., Türkçü, F. M., İşcan, Y. ve Yüksel, K. (2013). Single injection of triamcinolone versus three repeated injections of bevacizumab for treatment of diabetic macular edema. International Ophthalmology, 33(4), 375-380.
