Serotype distribution of Streptococcus pneumoniain children with invasive disease in Turkey: 2015-2018
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: To determine the serotype distribution of pneumococcus causing invasive pneumococcal
disease (meningitidis, bacteremia and empyema) in children in Turkey, and to observe potential changes
in this distribution in time to guide effective vaccine strategies.
Methods: We surveyed S. pneumoniae with conventional bacteriological techniques and with real-time
polymerase chain reaction (RT-PCR) in samples of cerebrospinal fluid (CSF), blood and pleural fluid.
S. pneumoniae strains were isolated from 33 different hospitals in Turkey, which are giving health
services to approximately 60% of the Turkish population.
Results: A total of 167 cases were diagnosed with invasive pneumococcal disease between 2015 and
2018. We diagnosed 52 (31.1%) patients with meningitis, 104 (62.2%) patients with bacteremia, and 11
(6.6%) patients with empyema. Thirty-three percent of them were less than 2 years old and 56% less
than 5 years old. Overall PCV13 serotypes accounted for 56.2% (94/167). The most common serotypes
were 19 F (11.9%), 1 (10.7%) and 3 (10.1%).
Conclusions: Besides the increasing frequency of non-vaccine serotypes, vaccine serotypes continue to
be a problem for Turkey despite routine and high-rate vaccination with PCV13 and significant reduction
reported for the incidence of IPD in young children. Since new candidate pneumococcal conjugate
vaccines with more serotype antigens are being developed, continuing IPD surveillance is a significant
source of information for decision-making processes on pneumococcal vaccination.
Açıklama
WOS:000545468700001
PMID: 32530357
PMID: 32530357
Anahtar Kelimeler
Epidemiology, Serotypes, Streptococcus pneumonia, Surveillance, Turkey
Kaynak
Human Vaccines & Immunotherapeutics
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
16
Sayı
11
Künye
Ceyhan, M., Aykaç, K., Gürler, N., Özsürekçi, Y., Öksüz, L., Akisoğlu, Ö.A. (2020). Serotype distribution of Streptococcus pneumoniain children with invasive disease in Turkey: 2015-2018. Human Vaccines & Immunotherapeutics, 16(11), 2773-2778.
