Expression of miRNA-451 and miRNA-885 in Meningiomas
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int Inst Anticancer Research
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/Aim: Meningiomas are one of the most common intracranial tumors, accounting for 30% of the tumors of the central nervous system. MicroRNAs (miRNAs) are noncoding RNAs containing approximately 18-22 nucleotides that regulate gene expression by interfering with transcription or inhibiting translation. Recent studies have reported that miRNAs could provide information about the molecular pathogenesis of several types of tumors. This study aimed to examine the expression levels of miRNA-885 and -451 and to determine their potential roles as biomarkers in meningioma. Materials and Methods: In total, 29 patients with meningioma (9 males and 20 females) were included in this study. The expression levels of miRNA were determined using real-time polymerase chain reaction. In addition, receiver operating characteristic curve analysis was used to analyze the predictive potential of miRNAs. Results: Our results indicated a significant increase in miRNA-451 expression levels (p=0.003); however, there was no significant change in miRNA-885 expression levels
Açıklama
Anahtar Kelimeler
Meningiomas, Microrna-451, Microrna-885, Gene Expression, Neuro-Oncology
Kaynak
In Vivo
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
37
Sayı
6
