Solid lipid nanoparticles and applications as brain specific drug delivery systems

Basit Öğe Kaydı
dc.contributor.authorToksoy, Mahmut Ozan
dc.contributor.authorTırnaksız, Fahriye Figen
dc.date.accessioned2024-04-24T17:58:15Z
dc.date.available2024-04-24T17:58:15Z
dc.date.issued2022
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Ana bilim Dalıen_US
dc.description.abstractObjective: In the last 20 years, with the nanotechnological developments, there has been an increase in studies aimed at targeting drug molecules to the brain. The brain is separated from bloodstream by a unique barrier. This structure, called the blood-brain barrier, which consists of astrocytes, pericytes, endothelial cells and tight junctions between them. Apart from the enzymatic activity that prevents the passage of molecules to the brain, the separation of the brain from the systemic blood circulation by the blood-brain barrier negatively affects the passage of therapeutic molecules. The structure of the brain and the blood-brain barrier must be known and the penetration mechanisms of drug molecules to the brain must be elucidated. In this review, we aimed to mention the blood-brain barrier and drug targeting methods to the brain. Also, importance of the solid lipid nanoparticles in targeting drug molecules to the brain will be emphasized. Result and Discussion: Blood-brain barrier is the biggest obstacle in targeting drug molecules to the brain. One of the systems developed to overcome this obstacle is solid lipid nanoparticles. It has been observed that the effectiveness of drugs in central nervous system disorders can be increased by targeting.en_US
dc.identifier.citationToksoy, M. O. ve Tırnaksız, F. F. (2022). Solid lipid nanoparticles and applications as brain specific drug delivery systems. Ankara Universitesi Eczacilik Fakultesi Dergisi, 46(2), 428-442.
dc.identifier.doi10.33483/jfpau.855788q
dc.identifier.endpage442en_US
dc.identifier.issn2564-6524
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85131310934en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.855788q
dc.identifier.urihttps://hdl.handle.net/11468/23767
dc.identifier.volume46en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood-Brain barrieren_US
dc.subjectDrug delivery systemsen_US
dc.subjectSolid lipid nanoparticlesen_US
dc.subjectTargeting to the brainen_US
dc.titleSolid lipid nanoparticles and applications as brain specific drug delivery systemsen_US
dc.title.alternativeKatı lipit nanopartiküller ve beyne özgü ilaç taşıyıcı sistem olarak uygulamalarıen_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu