Could moesin be a new marker for indicating progression in endometrial cancer?

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dc.authorid0000-0002-4215-1371en_US
dc.authorid0000-0002-3285-9990en_US
dc.authorid0000-0001-8468-7038en_US
dc.authorid0000-0002-1659-1189en_US
dc.authorid0000-0002-7168-1507en_US
dc.contributor.authorAğaçayak, Elif
dc.contributor.authorKeleş, Ayşenur
dc.contributor.authorDeğer, Uğur
dc.contributor.authorÖzçelik, Mehmet Şirin
dc.contributor.authorPeker, Nurullah
dc.contributor.authorGündüz, Reyhan
dc.contributor.authorAkkuş, Murat
dc.contributor.authorBüyükbayram, Hüseyin
dc.date.accessioned2023-03-28T06:54:38Z
dc.date.available2023-03-28T06:54:38Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractAim: This study aims to determine an important parameter in progression from pre-invasive lesions of endometrium to endometrial cancer and also evaluate the effect of this parameter on the progression of endometrial cancer. Material and Method: In our study,30 patients with normal endometrial tissue (group 1), 56 patients who had endometrial hyperplasia without atypia (group 2), 36 patients who had endometrial hyperplasia with atypia (group 3), and 63 patients with endometrial cancer (group 4) were included. Age, parity, body-mass index, systemic diseases, and tumor markers of patients were evaluated. Expression levels of Ezrin, Radixin, and Moesin proteins were immunohistochemically evaluated in terms of frequency, intensity, and score value. Results: When we compared hyperplasia cases with or without atypia; frequency, and score value of ezrin expression and frequency, intensity, and score value of moesin expression was significantly higher in patients who had hyperplasia with atypia (p:0.000 p:0.001 p:0.003, p:0.032 p: 0.035 p:0.015 p:0.005, respectively). It was observed that the frequency and score value of moesin expression were significantly higher in patients with endometrial cancer when compared with patients who had hyperplasia with atypia (p:0.003 p:0.045). The frequency of moesin expression was significantly higher in patients who had postoperative mortality (p:0.030 p:0.039). Conclusion: Increased frequency of moesin expression in the preoperative period in patients with atypical hyperplasia should alert the surgeon in terms of malignancy. If the frequency of moesin expression increases in cases with endometrial cancer, the patient should be followed closely in terms of progression in the postoperative period.en_US
dc.identifier.citationAğaçayak, E., Keleş, A., Değer, U., Özçelik, M.Ş., Peker, N., Gündüz, R. ve diğerleri. (2022). Could moesin be a new marker for indicating progression in endometrial cancer? Cancer Management and Research, 14, 1247-1257.en_US
dc.identifier.doi10.2147/CMAR.S353225
dc.identifier.endpage1257en_US
dc.identifier.issn1179-1322
dc.identifier.pmid35356595
dc.identifier.scopus2-s2.0-85128371314
dc.identifier.scopusqualityQ1
dc.identifier.startpage1247en_US
dc.identifier.urihttps://www.dovepress.com/getfile.php?fileID=79330
dc.identifier.urihttps://hdl.handle.net/11468/11534
dc.identifier.volume14en_US
dc.identifier.wosWOS:000778372800004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAğaçayak, Elif
dc.institutionauthorKeleş, Ayşenur
dc.institutionauthorÖzçelik, Mehmet Şirin
dc.institutionauthorPeker, Nurullah
dc.institutionauthorGündüz, Reyhan
dc.institutionauthorAkkuş, Murat
dc.institutionauthorBüyükbayram, Hüseyin
dc.language.isoenen_US
dc.publisherDove Medical Press Ltd.en_US
dc.relation.ispartofCancer Management and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperplasiaen_US
dc.subjectEndometrial canceren_US
dc.subjectMoesinen_US
dc.subjectProgressionen_US
dc.titleCould moesin be a new marker for indicating progression in endometrial cancer?en_US
dc.titleCould moesin be a new marker for indicating progression in endometrial cancer?
dc.typeArticleen_US

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