Development of AML in a patient who was in complete remission after limited stage small cell carcinoma of the lung: A case report

Concomitant thoracic irradiation and cisplatin and etoposide has been started at a 62 years old male patient with limited stage small cell carcinoma of the lung. Complete remission was achieved clinically and radiologically after 46 Gy irradiation and 4 cycle chemotherapy and prophylactic cranial irradiation was also applied. The patient was on complete remission for more than 6 months when he complained of malasia and hemogram revealed pancytopenia. Diagnosis of acute myeloblastic cell leukemia (AML) was reached with blood smear and bone marrow aspiration biopsy. AML-M2 diagnosis was confirmed with flowcytometry. Chemotherapy with cytosin-arabinoside and idarubicin was started. The patient has died at the 35th day of therapy with acute respiratory arrest. Death was dedicated to intracranial hemorrhage which caused by thrombocytopenia.