Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar)

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dc.authorid0000-0002-9017-763en_US
dc.contributor.authorÇetin, G.
dc.contributor.authorÇorum, O.
dc.contributor.authorÇorum, D. D.
dc.contributor.authorAtik, O.
dc.contributor.authorAltan, F.
dc.contributor.authorTürk, E.
dc.contributor.authorTekeli, I. O.
dc.contributor.authorFaki, H. E.
dc.contributor.authorUney, K.
dc.date.accessioned2021-12-17T08:58:53Z
dc.date.available2021-12-17T08:58:53Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Farmakoloji ve Toksikoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000727139900001
dc.descriptionPMID: 34633873
dc.description.abstract1. The aim of this study was to determine the pharmacokinetics of meloxicam (MLX, 1 mg/kg body weight (BW)), ketoprofen (KETO, 2 mg/kg BW), and tolfenamic acid (TA, 2 mg/kg BW) in chukar partridge (Alectoris chukar) following intravenous (IV) administration. 2. Twenty-four healthy chukar partridges were randomly divided into three equal groups (n = 8) as MLX, KETO and TA. Plasma concentrations of MLX, KETO and TA were measured using high-performance liquid chromatography-ultraviolet detection and analysed using non-compartmental analysis. 3. No adverse effects were determined in chukar partridges after IV administration of MLX, KETO and TA. MLX, KETO and TA were detected in plasma up to 10, 12 and 12 h, respectively. The terminal elimination half-life of MLX, KETO and TA was 1.22, 1.77 and 1.95 h, respectively. MLX, KETO and TA exhibited volumes of distribution at a steady-state of 0.03, 0.23 and 0.41 l/kg BW, respectively. The total plasma clearance of MLX, KETO and TA was 0.02, 0.11 and 0.15 l/h/kg, respectively. The extraction ratios for MLX, KETO and TA were calculated as 0.002, 0.011 and 0.016, respectively. 4. MLX, KETO and TA offer treatment in chukar partridges for various conditions with an absence of adverse reactions and properties such as short elimination half-life and low volume of distribution. However, there is a need to establish the safety and adverse effects of repeated administration, pharmacokinetics of other administration routes and pharmacological efficacy of MLX, KETO and TA in chukar partridges.en_US
dc.identifier.citationÇetin, G., Çorum, O., Çorum, D. D., Atik, O., Altan, F., Türk, E. ve diğerleri. (2021). Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar). British Poultry Science, Early Access.en_US
dc.identifier.doi10.1080/00071668.2021.1990211
dc.identifier.issn0007-1668
dc.identifier.issn1466-1799
dc.identifier.pmid34633873
dc.identifier.scopus2-s2.0-85121293739
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11468/8539
dc.identifier.volumeEarly Accessen_US
dc.identifier.wosWOS:000727139900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAltan, Feray
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofBritish Poultry Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChukar partridgeen_US
dc.subjectHPLC-UVen_US
dc.subjectKetoprofenen_US
dc.subjectMeloxicamen_US
dc.subjectTolfenamic aciden_US
dc.titlePharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar)en_US
dc.titlePharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar)
dc.typeArticleen_US

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