Serum leptin level in women with unexplained infertility
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Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: The aim of this study was to compare serum levels of leptin in women with unexplained infertility with fertile subjects. Material and method: Serum leptin levels of 27 infertile and 30 fertile women on day 3 of the menstrual cycle were assessed and compared in this prospective age and body mass index (BMI) comparable controlled study. Results: The mean age in the infertile group was 29.3 (range, 23-38), while this figure was 28.9 (range, 19-39) in the fertile group; the mean BMIs were 24.5 (range, 20.6-27.8) and 25.0 (range, 21.8-28.7), respectively. The mean serum leptin level was significantly higher in women with unexplained infertility compared with fertile subjects. Considering normal weight subjects, mean serum leptin levels were increased significantly in the unexplained infertile group compared with the fertile group (7.2 (range, 4.3-10.4) versus 3.5 (range, 1.9-6.2) ng/ml, respectively;p < 0.0001, Mann-Whitney U-test). The significant increase in serum leptin levels was observed also in overweight patients (6.8 (range, 1.3-5.2) versus 3.3 (range, 4.2-8.9) ng/ml, respectively; p < 0.0001, Mann-Whitney U-test). Conclusion: A significant difference in serum leptin levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Leptin, Pathophysiology, Serum Level, Unexplained Infertility
Kaynak
Journal of Reproductive Immunology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
75
Sayı
2
