Does the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?

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dc.contributor.authorOzen, F.
dc.contributor.authorKocak, N.
dc.contributor.authorYildirim, I. Halil
dc.contributor.authorHacimuto, G.
dc.contributor.authorSen, V.
dc.date.accessioned2024-04-24T17:33:30Z
dc.date.available2024-04-24T17:33:30Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Inflammation may play an important role in the etiopathology of febrile convulsions (FC). IL-1 beta is an important mediator of inflammation and fever is also important information of FCs. It is suggested that there may be a relationship between polymorphisms of IL-1 beta and FC. The aim of the present study is to investigate the polymorphic stituation of promoter region of IL-1 beta in two sites (-31 and -511) and assess the IL-1 RA VNTR polymorphisms in FC patients in comparison with healthy control groups. MATERIALS AND METHODS: Fifty FC patients and 50 healthy controls (HC) were included in the study. DNA extraction was performed by QIAamp DNA Mini Kit from peripheral blood lymphocytes of all subjects. IL-1 beta promoter polymorphisms were analyzed by PCR-RFLP, IL-1 RA VNTR polymorphisms were analyzed by PCR-agarose gel electrophoresis. RESULTS: Genotype distribution of IL-1 beta promoter region in position -31 was statistically different between FC patients and control groups. Allele I and allele II of IL-1 RA distribution were also statistically different in FC patients and healthy controls. CONCLUSIONS: We have found a significant association between IL-1 RA allele distribution and FC and a poor correlation of T/C substitution at the -31 position of IL-1 beta promoter in FC. Further studies are needed to investigate the gene expression levels and polymorphic situation in same samples.en_US
dc.identifier.endpage124en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid26813462
dc.identifier.scopus2-s2.0-84958037583
dc.identifier.scopusqualityQ2
dc.identifier.startpage120en_US
dc.identifier.urihttps://hdl.handle.net/11468/20723
dc.identifier.volume20en_US
dc.identifier.wosWOS:000369544000019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFebrile Convulsionsen_US
dc.subjectInterleukin-1 Betaen_US
dc.subjectPromoteren_US
dc.subjectPolymorphismen_US
dc.subjectIl 1-Raen_US
dc.titleDoes the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?en_US
dc.titleDoes the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?
dc.typeArticleen_US

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