Effects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteins

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dc.authorid0000-0002-0288-7886en_US
dc.contributor.authorYıldız, Barış
dc.contributor.authorKamiloğlu, Nadide Nabil
dc.contributor.authorÖziç, Cem
dc.contributor.authorCoşkun, Yüksel
dc.date.accessioned2022-07-05T06:51:39Z
dc.date.available2022-07-05T06:51:39Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionWOS:000631279700001
dc.description.abstractThe aim of the present study was to determine the mRNA expression profiles of TRAIL-mediated cell death related genes of the hypoxia-tolerant rodent Nannospalax nehringi under hypoxia. The nucleotide and amino acid sequences of these genes were identified. Captured Nannospalax nehringi were randomly divided into normoxia and hypoxia groups. The hypoxia group was exposed to a 7% O-2 + 93% N-2 gas mixture for 52 h, while animals in the normoxia group were housed under normoxic conditions. Total RNAs were isolated from brain and lung tissues. The cIAP-1, cIAP-2, XIAP, DcR1, DcR2, FLIP and OPG genes were PCR amplified, and the cIAP-1, cIAP-2, XIAP, OPG, TRAIL and FLIP genes were sequenced. Sequenced genes were translated into amino acid sequences and compared with reliable sequences of closely similar species. The genes in the brain were regulated for protection against hypoxia; however, the genes in the lung were regulated differently. Many mutations and insertions were observed on the conserved regions of the cIAP-1, cIAP-2, XIAP, OPG and TRAIL genes in N. nehringi. We propose that these gene mutations and insertions contribute to the anti-hypoxic properties of N. nehringien_US
dc.identifier.citationYıldız, B., Kamiloğlu, N.N., Öziç, C. ve Coskun, Y. (2021). Effects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteins. Archives of Biological Science, 73(1), 5-15. http://doi.org/10.2298/ABS201119053Yen_US
dc.identifier.doi10.2298/ABS201119053Y
dc.identifier.endpage15en_US
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85103490286
dc.identifier.scopusqualityQ3
dc.identifier.startpage5en_US
dc.identifier.urihttp://www.doiserbia.nb.rs/img/doi/0354-4664/2021/0354-46642000053Y.pdf
dc.identifier.urihttps://hdl.handle.net/11468/10109
dc.identifier.volume73en_US
dc.identifier.wosWOS:000631279700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCoşkun, Yüksel
dc.language.isoenen_US
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovicen_US
dc.relation.ispartofArchives of Biological Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectNannospalax nehringien_US
dc.subjectHypoxiaen_US
dc.subjectTNF related apoptosis inducing ligand (TRAIL)en_US
dc.subjectInhibitors of apoptosis (IAPs)en_US
dc.subjectFLICE-like inhibitory protein (FLIP)en_US
dc.titleEffects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteinsen_US
dc.titleEffects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteins
dc.typeArticleen_US

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