p-Cymene based organometallic ruthenium(II)-arene complexes with benzaldehyde derived thiosemicarbazones: synthesis, characterization and antimicrobial activity

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dc.authorid19685en_US
dc.authorid7030en_US
dc.authorid12722en_US
dc.authorid0000-0003-3452-8551en_US
dc.authorid0000-0003-0376-2177en_US
dc.authorid0000-0002-9026-6376en_US
dc.authorid0000-0002-1981-7577en_US
dc.authorid0000-0003-0967-0767en_US
dc.contributor.authorYavuz, Murat
dc.contributor.authorYaman, Pelin Köse
dc.contributor.authorÖztürk, Nurdan
dc.contributor.authorTimur, Suna
dc.contributor.authorSubaşı, Elif
dc.date.accessioned2020-02-21T12:55:06Z
dc.date.available2020-02-21T12:55:06Z
dc.date.issued2017
dc.departmentChemistry Department, Faculty of Science, Dicle Universityen_US
dc.description.abstractObjective: Thiosemicarbazone (TSC) containing three new mononuclear ruthenium(II)-arene complexes were synthesized so as to contribute to the development of ruthenium complexes with pharmacologically attracted properties.Methods: Reactions of the ruthenium(II)-arene dimer [{RuCl(μ-Cl)(η6-p-cymene)}2] (1) with the respective TSC1-3 (1:2 molar ratio) in methanol resulted in p-cymene containing new conformationally rigid half-sandwich organometallic ruthenium(II)-arene complexes; [(η6-p-cymene)Ru(TSC1-κ3O,N,S)]Cl (I), [(η6-p-cymene)Ru(Cl)(TSC2-κ2N,S)]Cl (II), and [(η6-p-cymene)Ru(Cl)(TSC3- κ2N,S)]Cl (III). The molecular structures of complexes I, II and III were elucidated on the spectroscopic data obtained by the application of 1H NMR, Fourier transform infrared (FT-IR), UV-vis and elemental analysis techniques. In vitro antimicrobial activities of the synthesized three ruthenium(II)-arene complexes were evaluated using the disc diffusion method. Results: The spectroscopic data indicated that TSC1 was bounded to the metal as a tridentate ligand with its thione sulfur atom, phenolic oxygen atom and azomethine nitrogen atom in the complex I, while TSC2 and TSC3 were bounded to metal center as bidentate manner through their thione sulfur atom and imine nitrogen (C=N) atom in the complexes II and III, respectively. The obtained antimicrobial activity results showed that these complexes efficiently inhibit the growth of Gram-positive bacterial strains. Conclusion: The TSC1-3 containing ruthenium(II)-arene complexes were successfully synthesized and their molecular structures were also determined by the spectroscopic methods. All ruthenium(II)-arene complexes showed higher antibacterial activities against Gram-positive bacterial strains than the Gram-negative ones.en_US
dc.description.abstractAmaç: Farmakolojik olarak ilgi çekici özelliklere sahip rutenyum komplekslerinin gelişimine katkıda bulunmak amacıyla tiyosemikarbazon (TSC) içeren üç yeni mononükleer rutenyum(II)-aren kompleksleri sentezlendi. Yöntemler: Rutenyum(II)-aren dimeri [{RuCl(μ-Cl)(η6-p-simen)}2] (1) sırasıyla TSC1-3 (1:2 molar oranda) ile metanol içerisindeki reaksiyonu sonucu p-simen içeren konformasyonel olarak rijit yarı-sandviç Ru(II)-aren kompleksleri; [(η6-p-simen)Ru(TSC1-κ 3O,N,S)]Cl (I), [(η6-p-simen)Ru(Cl)(TSC2-κ 2N,S)]Cl (II), ve [(η6-p-simen)Ru(Cl)(TSC3-κ 2N,S)]Cl (III) bileşikleri sentezlendi. Kompleks I, II ve III’ün moleküler yapıları elementel analiz teknikleri ve 1H NMR, Fourier transform infrared (FT-IR), UV-vis uygulamaları ile elde edilen spektroskopik veriler temelinde aydınlatıldı. Sentezlenen üç rutenyum(II)-aren kompleksinin in vitro antimikrobiyal aktivitesi disk difüzyon metodu ile değerlendirildi. Bulgular: Spektroskopik veriler TSC1’in kompleks I’de tiyon sülfür atomu, fenolik oksijen atomu ve azometin azot atomu üzerinden üç-dişli ligant olarak metale bağlanırken, TSC2 ve TSC3’ün kompleks II ve III’te tiyon sülfür atomu ve imin azot (C=N) atomu üzerinden çift-dişli ligant olarak merkezi metal atomuna bağlandığını ortaya koymuştur. Gözlemlenen antimikrobiyal aktivite sonuçları komplekslerin Gram-pozitif bakteri suşlarının büyümelerini etkin bir biçimde inhibe ettiğini göstermiştir. Sonuç: TSC1-3 içeren yeni mononükleer rutenyum(II)-aren kompleksleri başarılı bir biçimde sentezlendi ve moleküler yapıları spektroskopik yöntemlerle belirlendi. Bütün rutenyum(II)-aren kompleksleri Gram-negatif bakterilerden ziyade Gram-pozitif bakterilere karşı yüksek antimikrobiyal aktivite gösterdi.en_US
dc.identifier.citationYavuz, M., Yaman, P.K., Öztürk, N., Timur, S., Subaşı, E. (2017). p-Cymene based organometallic ruthenium(II)-arene complexes with benzaldehyde derived thiosemicarbazones: synthesis, characterization and antimicrobial activity. Dicle Tıp Dergisi, 44(4), 381-394en_US
dc.identifier.doi10.5798/dicletip.362482
dc.identifier.endpage394en_US
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue4en_US
dc.identifier.startpage381en_US
dc.identifier.trdizinid282046
dc.identifier.urihttps://hdl.handle.net/11468/4493
dc.identifier.urihttps://app.trdizin.gov.tr/publication/paper/detail/TWpneU1EUTJOZz09
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/282046
dc.identifier.volume44en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherDicle Üniversitesi Tıp Fakültesien_US
dc.relation.ispartofDicle Tıp Dergisi
dc.relation.publicationcategory0-Belirleneceken_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectHalf-sandwich Ru(II)-arene complexesen_US
dc.subjectBenzaldehyde thiosemicarbazoneen_US
dc.subjectp-cymeneen_US
dc.subjectAntimicrobial activityen_US
dc.subjectClinical isolateen_US
dc.subjectYarı-sandviç Ru(II)-aren kompleksleren_US
dc.subjectBenzaldehit tiyosemikarbazonlaren_US
dc.subjectp-simenen_US
dc.subjectAntimikrobiyal aktiviteen_US
dc.subjectKlinik izolaten_US
dc.titlep-Cymene based organometallic ruthenium(II)-arene complexes with benzaldehyde derived thiosemicarbazones: synthesis, characterization and antimicrobial activityen_US
dc.titlep-Cymene based organometallic ruthenium(II)-arene complexes with benzaldehyde derived thiosemicarbazones: synthesis, characterization and antimicrobial activity
dc.title.alternativeBenzaldehitten türemiş tiyosemikarbazon içeren p-Simen temelli organometalik rutenyum(II)-aren kompleksler: sentezi, karakterizasyonu ve antimikrobiyal aktivitesien_US
dc.title.alternativeBenzaldehitten türemiş tiyosemikarbazon içeren p-Simen temelli organometalik rutenyum(II)-aren kompleksler: sentezi, karakterizasyonu ve antimikrobiyal aktivitesi
dc.typeArticleen_US

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