Akut nekrotizan pankreatitli hastalarda cerrahi tedavi sonuçları ve mortaliteye etkili faktörler
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Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Modestum Publishing Ltd.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Akut nekrotizan pankreatit, seyri sırasında parankim nekrozu geliştiği için şiddetli akut pankreatit ile özdeşleşmiş, morbidite ve mortalitesi hala yüksek olan bir durumdur. Bu çalışmadaki amacımız akut nekrotizan pankreatit nedeniyle cerrahi uygulanan hastalarda mortaliteyi etkileyen faktörleri incelemek ve cerrahi tedavi sonuçlarımızı sunmaktır. Gereç ve yöntem: Kliniğimizde 2006-2012 yılları arasında akut nekrotizan pankreatit nedeniyle ameliyat edilen 38 hastanın özellikleri, Ranson ve APACHE II skorları retrospektif olarak kaydedildi. Bulgular: Çalışmaya dahil edilen hastaların 11’i (%28.9) erkek, 27’si (%71.1) kadın ve yaş ortalamaları 55.1±16.0 idi. Yaş, C-reaktif protein, amilaz ve karaciğer enzimleri, pankreatit etiyolojisi, ameliyat sonrası görülen komplikasyonlar ile mortalite arasında ilişki saptanamadı (p>0.05). Beyaz küre değerleri, nekroz alanının genişliği, başvuru anındaki APACHE II ve Ranson değerlerinin mortalite üzerindeki ilişkisi anlamlı idi (p<0.05). Sonuç: Akut nekrotizan pankreatit tedavisi zor ve mortalite oranları hala yüksek seyreden bir hastalıktır. Çalışmamızda hastaların beyaz küre değerleri, Ranson değerleri, APACHE II skorlarının ve nekroz genişliğinin mortalite üzerine negatif etkili olduğunu saptadık. Hasta stabilize edilemiyorsa veya cerrahi için gereken endikasyonlar varsa, hasta ameliyat edilebilecek duruma gelir gelmez cerrahi planlanmalıdır.
Objectives: Acute necrotizing pancreatitis is a condition still with high morbidity and mortality which is associated with severe acute pancreatitis because parenchyma necrosis occurs during illness. Our aim in this study is to examine the factors affecting mortality in patients undergoing surgery because of acute necrotizing pancreatitis and present our surgical outcomes. Materials and methods: The clinical features, Ranson and APACHE II scores of 38 patients operated in clinic (2006-2012) for acute necrotizing pancreatitis were recorded retrospectively. Results: From the patients included in the study, 11 (28.9%) were male and 27 (71.1%) were female with an age average of 55.1±16.0 years. No relationship was found between age, C-reactive proteins, amylase and liver enzymes, pancreatitis etiology, complications seen after surgery and mortality (p>0.05). The effects of white blood cell values, width of necrosis area and the APACHE II and Ranson values upon admission on mortality were significant (p<0.05). Conclusions: Acute necrotizing pancreatitis is a disease difficult to treat with mortality rates remaining high. In our study we determined that the patients&#8217; white blood cellcounts, Ranson values, APACHE II scores and necrosis width had negative effects on mortality. If the patient cannot be stabilized or there are indications required for the surgery, surgery must be planned as soon as the patient is suitable for operation. J Clin Exp Invest 2012; 3(4): 500- 504.
Objectives: Acute necrotizing pancreatitis is a condition still with high morbidity and mortality which is associated with severe acute pancreatitis because parenchyma necrosis occurs during illness. Our aim in this study is to examine the factors affecting mortality in patients undergoing surgery because of acute necrotizing pancreatitis and present our surgical outcomes. Materials and methods: The clinical features, Ranson and APACHE II scores of 38 patients operated in clinic (2006-2012) for acute necrotizing pancreatitis were recorded retrospectively. Results: From the patients included in the study, 11 (28.9%) were male and 27 (71.1%) were female with an age average of 55.1±16.0 years. No relationship was found between age, C-reactive proteins, amylase and liver enzymes, pancreatitis etiology, complications seen after surgery and mortality (p>0.05). The effects of white blood cell values, width of necrosis area and the APACHE II and Ranson values upon admission on mortality were significant (p<0.05). Conclusions: Acute necrotizing pancreatitis is a disease difficult to treat with mortality rates remaining high. In our study we determined that the patients&#8217; white blood cellcounts, Ranson values, APACHE II scores and necrosis width had negative effects on mortality. If the patient cannot be stabilized or there are indications required for the surgery, surgery must be planned as soon as the patient is suitable for operation. J Clin Exp Invest 2012; 3(4): 500- 504.
Açıklama
Anahtar Kelimeler
Akut nekratizan pankreatit, Cerrahi tedavi, Mortalite, Acute necrotizing pancreatitis, Surgical treatment, Mortality
Kaynak
Journal of Clinical and Experimental Investigations
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
4
Künye
Aliosmanoğlu, İ., Gül, M., Tekeş, F., Türkoğlu, A., Ülger, B. V., Uslukaya, Ö. ve diğerleri. (2012). Akut nekrotizan pankreatitli hastalarda cerrahi tedavi sonuçları ve mortaliteye etkili faktörler. Journal of Clinical and Experimental Investigations, 3(4), 500-504.
