The effect of mesenchymal stem cells, demineralized bone graft and platelet-rich plasma on osteogenesis in rat tibia defects

Basit Öğe Kaydı
dc.authorid0000-0002-9706-3862en_US
dc.authorid0000-0002-2456-7381en_US
dc.contributor.authorErdoğmuş, Zozan
dc.contributor.authorGülsün, Belgin
dc.date.accessioned2022-10-03T12:14:51Z
dc.date.available2022-10-03T12:14:51Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Ağız-Diş-Çene Hastalıkları ve Cerrahisi Bölümüen_US
dc.description.abstractAim: Deformities of the jaw and face are often caused by infection, inflammation, and cystic and neoplastic pathological conditions. Defects with various aetiologies should be repaired promptly using the most appropriate approach to reconstruct the anatomical form. To treat defects, bone grafts with various combinations have been used. In particular, combinations including cellular products to enhance osteogenic properties have been implemented. In this study, we aimed to investigate the effects of different materials and cells on bone defects by using mesenchymal stem cells (MSCs), which are thought to have a positive effect on healing, demineralized bone graft (DMB) and platelet-rich plasma (PRP). Methodology: We used 55 female rats weighing between 200-250 g, four of which were used to obtain platelet-rich plasma. The remaining animals were divided into five groups. Group I (n = 6) was the operative control group, Group II (n = 24) was given DMB, Group III (n = 24) was given DMB+PRP, Group IV (n = 24) was given MSC+DBG and Group V (n = 24) was given DMB+PRP+MSC applied to rat tibial defects (10 mm x 3 mm x 2 mm). Results: Statistically significant differences were observed in bone osteoblastic activity in tibia defects among the groups (p<0.05). Conclusion: Bone regeneration was significantly improved in groups where MSCs were used in combination with DMB and PRP.en_US
dc.identifier.citationErdoğmuş, Z. ve Gülsün, B. (2021). The effect of mesenchymal stem cells, demineralized bone graft and platelet-rich plasma on osteogenesis in rat tibia defects. International Dental Research, 11(Supplement 1), 47-55.en_US
dc.identifier.doi10.5577/intdentres.2021.vol11.suppl1.8
dc.identifier.endpage55en_US
dc.identifier.issn2146-1767
dc.identifier.issueSupplement 1en_US
dc.identifier.startpage47en_US
dc.identifier.trdizinid516626
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/516626
dc.identifier.urihttps://hdl.handle.net/11468/10600
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/516626
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorGülsün, Belgin
dc.language.isoenen_US
dc.publisherUluslararası Diş Araştırmaları Birliğien_US
dc.relation.ispartofInternational Dental Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone defecten_US
dc.subjectDemineralized bone graften_US
dc.subjectMesenchymal stem cellen_US
dc.subjectPlatelet rich plasmaen_US
dc.subjectRaten_US
dc.titleThe effect of mesenchymal stem cells, demineralized bone graft and platelet-rich plasma on osteogenesis in rat tibia defectsen_US
dc.titleThe effect of mesenchymal stem cells, demineralized bone graft and platelet-rich plasma on osteogenesis in rat tibia defects
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
The effect of mesenchymal stem cells, demineralized bone.pdf
Boyut:
644.13 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diş Hekimliği Fakültesi Ağız Diş Çene Cerrahisi Anabilim Dalı Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu