The effects of epidermal growth factor deficiency on rat gingival epithelia

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dc.contributor.authorKetan? M.A.
dc.contributor.authorDağ A.
dc.contributor.authorZeng?ngül A.?.
dc.contributor.authorBüyükbayram H.
dc.contributor.authorÖzbağ D.
dc.date.accessioned2024-04-24T18:43:57Z
dc.date.available2024-04-24T18:43:57Z
dc.date.issued2001
dc.departmentDicle Üniversitesien_US
dc.description.abstractEpidermal growth factor (EGF) is a low molecular mass polypeptide with 53 amino acids and is known to stimulate cell proliferation and differentiation in a wide range of tissues. EGF is thought to have important functions in epithelial growth and differentiation and in wound healing. In the present study, the teratogenic effects of sialoadenectomy on rat gingival epithelia were investigated histologically. Twenty adult female Wistar albino rats were divided into two groups (N = 10), a control and an experimental group. The experimental group was subjected to sialoadenectomy in order to create EGF deficiency. After 60 days of sialoadenectomy (EGF deficiency), control group rats were killed using pentobarbital and their maxilla removed. The sections were stained with haematoxylineosin and Mason triple for evaluation by using a light microscope. Astatistically significant reduction in body mass was noted in rats in the experimental group when compared to the control group. Decreasing the thickness of keratization layer, irregularity and disappearance of microscopic papilla, intraepithelial focal cystic lesions resulting from EGF deficiency, and a decrease in saliva, were noted. As a result, epidermal growth factor deficiency performed by sialoadenectomy caused body mass reduction and gingival epithelia abnormalities.en_US
dc.identifier.endpage96en_US
dc.identifier.issn0372-5480
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0035560393
dc.identifier.scopusqualityQ4
dc.identifier.startpage85en_US
dc.identifier.urihttps://hdl.handle.net/11468/24483
dc.identifier.volume71en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofVeterinarski Arhiv
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectGingival Epitheliaen_US
dc.subjectSialoadenectomyen_US
dc.titleThe effects of epidermal growth factor deficiency on rat gingival epitheliaen_US
dc.titleThe effects of epidermal growth factor deficiency on rat gingival epithelia
dc.typeArticleen_US

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